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Projecting hospital utilization during the COVID-19 outbreaks in the United States.
Moghadas, Seyed M; Shoukat, Affan; Fitzpatrick, Meagan C; Wells, Chad R; Sah, Pratha; Pandey, Abhishek; Sachs, Jeffrey D; Wang, Zheng; Meyers, Lauren A; Singer, Burton H; Galvani, Alison P.
  • Moghadas SM; Agent-Based Modelling Laboratory, York University, Toronto, ON M3J 1P3, Canada.
  • Shoukat A; Center for Infectious Disease Modeling and Analysis, Yale School of Public Health, New Haven, CT 06510.
  • Fitzpatrick MC; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Wells CR; Center for Infectious Disease Modeling and Analysis, Yale School of Public Health, New Haven, CT 06510.
  • Sah P; Center for Infectious Disease Modeling and Analysis, Yale School of Public Health, New Haven, CT 06510.
  • Pandey A; Center for Infectious Disease Modeling and Analysis, Yale School of Public Health, New Haven, CT 06510.
  • Sachs JD; Center for Sustainable Development at Columbia University, Columbia University, New York, NY 10032.
  • Wang Z; Department of Biostatistics, Yale School of Public Health, New Haven, CT 06510.
  • Meyers LA; Department of Integrative Biology, The University of Texas at Austin, Austin, TX 78712.
  • Singer BH; Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610 bhsinger@epi.ufl.edu.
  • Galvani AP; Center for Infectious Disease Modeling and Analysis, Yale School of Public Health, New Haven, CT 06510.
Proc Natl Acad Sci U S A ; 117(16): 9122-9126, 2020 04 21.
Article in English | MEDLINE | ID: covidwho-34058
ABSTRACT
In the wake of community coronavirus disease 2019 (COVID-19) transmission in the United States, there is a growing public health concern regarding the adequacy of resources to treat infected cases. Hospital beds, intensive care units (ICUs), and ventilators are vital for the treatment of patients with severe illness. To project the timing of the outbreak peak and the number of ICU beds required at peak, we simulated a COVID-19 outbreak parameterized with the US population demographics. In scenario analyses, we varied the delay from symptom onset to self-isolation, the proportion of symptomatic individuals practicing self-isolation, and the basic reproduction number R0 Without self-isolation, when R0 = 2.5, treatment of critically ill individuals at the outbreak peak would require 3.8 times more ICU beds than exist in the United States. Self-isolation by 20% of cases 24 h after symptom onset would delay and flatten the outbreak trajectory, reducing the number of ICU beds needed at the peak by 48.4% (interquartile range 46.4-50.3%), although still exceeding existing capacity. When R0 = 2, twice as many ICU beds would be required at the peak of outbreak in the absence of self-isolation. In this scenario, the proportional impact of self-isolation within 24 h on reducing the peak number of ICU beds is substantially higher at 73.5% (interquartile range 71.4-75.3%). Our estimates underscore the inadequacy of critical care capacity to handle the burgeoning outbreak. Policies that encourage self-isolation, such as paid sick leave, may delay the epidemic peak, giving a window of time that could facilitate emergency mobilization to expand hospital capacity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Patient Acceptance of Health Care / Disease Outbreaks / Coronavirus Infections / Pandemics / Hospital Bed Capacity / Hospitals / Intensive Care Units Type of study: Observational study / Prognostic study Limits: Humans Country/Region as subject: North America Language: English Journal: Proc Natl Acad Sci U S A Year: 2020 Document Type: Article Affiliation country: Pnas.2004064117

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Patient Acceptance of Health Care / Disease Outbreaks / Coronavirus Infections / Pandemics / Hospital Bed Capacity / Hospitals / Intensive Care Units Type of study: Observational study / Prognostic study Limits: Humans Country/Region as subject: North America Language: English Journal: Proc Natl Acad Sci U S A Year: 2020 Document Type: Article Affiliation country: Pnas.2004064117