The Landscape of Human Cancer Proteins Targeted by SARS-CoV-2.

Tutuncuoglu, Beril; Cakir, Merve; Batra, Jyoti; Bouhaddou, Mehdi; Eckhardt, Manon; Gordon, David E; Krogan, Nevan J

Tutuncuoglu, Beril; Cakir, Merve; Batra, Jyoti; Bouhaddou, Mehdi; Eckhardt, Manon; Gordon, David E; Krogan, Nevan J.

Tutuncuoglu B; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California.
Cakir M; The J. David Gladstone Institutes, San Francisco, California.
Batra J; Quantitative Biosciences Institute, University of California, San Francisco, California.
Bouhaddou M; QBI COVID-19 Research Group (QCRG), San Francisco, California.
Eckhardt M; The Cancer Cell Map Initiative (CCMI), University of California, San Francisco, California, and University of California, San Diego, La Jolla, California.
Gordon DE; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California.
Krogan NJ; The J. David Gladstone Institutes, San Francisco, California.

Cancer Discov ; 10(7): 916-921, 2020 07.

Article in English | MEDLINE | ID: covidwho-342772

ABSTRACT

ABSTRACT

The mapping of SARS-CoV-2 human protein-protein interactions by Gordon and colleagues revealed druggable targets that are hijacked by the virus. Here, we highlight several oncogenic pathways identified at the host-virus interface of SARS-CoV-2 to enable cancer biologists to apply their knowledge for rapid drug repurposing to treat COVID-19, and help inform the response to potential long-term complications of the disease.

Subject(s)

Betacoronavirus; Coronavirus Infections/drug therapy; Drug Repositioning; Neoplasm Proteins/antagonists & inhibitors; Neoplasms/drug therapy; Pneumonia, Viral/drug therapy; COVID-19; Cell Cycle; Coronavirus Infections/genetics; Coronavirus Infections/metabolism; Coronavirus Infections/physiopathology; DNA Damage; Epigenomics; Humans; Neoplasm Proteins/drug effects; Neoplasms/genetics; Neoplasms/metabolism; Neoplasms/physiopathology; Pandemics; Pneumonia, Viral/genetics; Pneumonia, Viral/metabolism; Pneumonia, Viral/physiopathology; Protein Biosynthesis; SARS-CoV-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Drug Repositioning / Betacoronavirus / Neoplasm Proteins / Neoplasms Limits: Humans Language: English Journal: Cancer Discov Year: 2020 Document Type: Article

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