Adaptive Flexible Sialylated Nanogels as Highly Potent Influenza A Virus Inhibitors.
Angew Chem Int Ed Engl
; 59(30): 12417-12422, 2020 07 20.
Article
in English
| MEDLINE | ID: covidwho-343407
ABSTRACT
Flexible multivalent 3D nanosystems that can deform and adapt onto the virus surface via specific ligand-receptor multivalent interactions can efficiently block virus adhesion onto the cell. We here report on the synthesis of a 250â
nm sized flexible sialylated nanogel that adapts onto the influenza A virus (IAV) surface via multivalent binding of its sialic acid (SA) residues with hemagglutinin spike proteins on the virus surface. We could demonstrate that the high flexibility of sialylated nanogel improves IAV inhibition by 400 times as compared to a rigid sialylated nanogel in the hemagglutination inhibition assay. The flexible sialylated nanogel efficiently inhibits the influenza A/X31 (H3N2) infection with IC50 values in low picomolar concentrations and also blocks the virus entry into MDCK-II cells.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Influenza A virus
/
N-Acetylneuraminic Acid
/
Nanogels
Limits:
Animals
Language:
English
Journal:
Angew Chem Int Ed Engl
Year:
2020
Document Type:
Article
Affiliation country:
Anie.202006145
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