Survival of COVID-19 patients requires precise immune regulation: The hypothetical immunoprotective role of nicotinic agonists.

Allahverdi Khani, M; SalehiRad, M; Darbeheshti, S; Motaghinejad, M

Allahverdi Khani, M; SalehiRad, M; Darbeheshti, S; Motaghinejad, M.

Allahverdi Khani M; Clinical Research Development Center, Najafabad Branch, Islamic Azad University, Najafabad, Iran. Electronic address: Allahverdy.maryam@yahoo.com.
SalehiRad M; Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Darbeheshti S; Department of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Motaghinejad M; Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran.

Med Hypotheses ; 143: 109871, 2020 Oct.

Article in English | MEDLINE | ID: covidwho-343478

ABSTRACT

ABSTRACT

recent studies have provided novel evidence regarding the effect of nicotine agonists on the prevention or modulation of cytokines storm and reduction of infection. In this study we tried to attempt to address these issues from a therapeutic perspective of nicotine agonists in this manner and we describe one of the most challenging theories of immunotherapy in coronavirus-19 (COVID-19). The analysis of the proposed mechanism goes beyond the physiological consequences of a way to design new strategies to provide anti-inflammatory drugs.

Subject(s)

Anti-Inflammatory Agents/administration & dosage; Coronavirus Infections/drug therapy; Coronavirus Infections/immunology; Immune System/drug effects; Immune System/virology; Nicotinic Agonists/administration & dosage; Pneumonia, Viral/drug therapy; Pneumonia, Viral/immunology; Anti-Inflammatory Agents/therapeutic use; Betacoronavirus; Biomarkers/metabolism; COVID-19; Cholinergic Agents/therapeutic use; Coronavirus Infections/mortality; Cytokines/metabolism; Humans; Immunotherapy; Inflammation; Nicotine/metabolism; Pandemics; Pneumonia, Viral/mortality; Receptors, Nicotinic/metabolism; SARS-CoV-2; Survivors; Treatment Outcome

Keywords

COVID-19; Immunotherapy; Nicotinic agonist

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Nicotinic Agonists / Immune System / Anti-Inflammatory Agents Type of study: Prognostic study Limits: Humans Language: English Journal: Med Hypotheses Year: 2020 Document Type: Article

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