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COVID-19, an opportunity to reevaluate the correlation between long-term effects of anthropogenic pollutants on viral epidemic/pandemic events and prevalence.
Tsatsakis, Aristidis; Petrakis, Demetrious; Nikolouzakis, Taxiarchis Konstantinos; Docea, Anca Oana; Calina, Daniela; Vinceti, Marco; Goumenou, Marina; Kostoff, Ronald N; Mamoulakis, Charalampos; Aschner, Michael; Hernández, Antonio F.
  • Tsatsakis A; Laboratory of Toxicology, Medical School, University of Crete, Voutes, 71409 Heraklion, Crete, Greece; Department of Analytical and Forensic Medical Toxicology, Sechenov University, 2-4 Bolshaya Pirogovskaya st., 119991 Moscow, Russia; Department of Molecular Pharmacology, Albert Einstein College of
  • Petrakis D; Laboratory of Toxicology, Medical School, University of Crete, Voutes, 71409 Heraklion, Crete, Greece. Electronic address: dimitriospetrakis@hotmail.com.
  • Nikolouzakis TK; Laboratory of Toxicology, Medical School, University of Crete, Voutes, 71409 Heraklion, Crete, Greece. Electronic address: konstan10@hotmail.gr.
  • Docea AO; Department of Toxicology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. Electronic address: ancadocea@gmail.com.
  • Calina D; Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. Electronic address: calinadaniela@gmail.com.
  • Vinceti M; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, I-41125 Modena, Italy. Electronic address: marco.vinceti@unimore.it.
  • Goumenou M; Laboratory of Toxicology, Medical School, University of Crete, Voutes, 71409 Heraklion, Crete, Greece.
  • Kostoff RN; School of Public Policy, Georgia Institute of Technology, Gainesville, VA, 20155, USA. Electronic address: rkostoff@gmail.com.
  • Mamoulakis C; Department of Urology, University General Hospital of Heraklion, Medical School, University of Crete, 71003 Heraklion, Crete, Greece. Electronic address: mamoulak@uoc.gr.
  • Aschner M; Department of Analytical and Forensic Medical Toxicology, Sechenov University, 2-4 Bolshaya Pirogovskaya st., 119991 Moscow, Russia; Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, NY 10461, USA. Electronic address: michael.Aschner@einstein.yu.edu.
  • Hernández AF; Department of Legal Medicine and Toxicology, University of Granada School of Medicine, 180016 Granada, Spain. Electronic address: ajerez@ugr.es.
Food Chem Toxicol ; 141: 111418, 2020 Jul.
Article in English | MEDLINE | ID: covidwho-345861
ABSTRACT
Occupational, residential, dietary and environmental exposures to mixtures of synthetic anthropogenic chemicals after World War II have a strong relationship with the increase of chronic diseases, health cost and environmental pollution. The link between environment and immunity is particularly intriguing as it is known that chemicals and drugs can cause immunotoxicity (e.g., allergies and autoimmune diseases). In this review, we emphasize the relationship between long-term exposure to xenobiotic mixtures and immune deficiency inherent to chronic diseases and epidemics/pandemics. We also address the immunotoxicologic risk of vulnerable groups, taking into account biochemical and biophysical properties of SARS-CoV-2 and its immunopathological implications. We particularly underline the common mechanisms by which xenobiotics and SARS-CoV-2 act at the cellular and molecular level. We discuss how long-term exposure to thousand chemicals in mixtures, mostly fossil fuel derivatives, exposure toparticle matters, metals, ultraviolet (UV)-B radiation, ionizing radiation and lifestyle contribute to immunodeficiency observed in the contemporary pandemic, such as COVID-19, and thus threaten global public health, human prosperity and achievements, and global economy. Finally, we propose metrics which are needed to address the diverse health effects of anthropogenic COVID-19 crisis at present and those required to prevent similar future pandemics.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pesticides / Pneumonia, Viral / Xenobiotics / Coronavirus Infections / Air Pollutants / Betacoronavirus Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Animals / Humans Language: English Journal: Food Chem Toxicol Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pesticides / Pneumonia, Viral / Xenobiotics / Coronavirus Infections / Air Pollutants / Betacoronavirus Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Animals / Humans Language: English Journal: Food Chem Toxicol Year: 2020 Document Type: Article