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Sodium status and kidney involvement during COVID-19 infection.
Post, Adrian; Dullaart, Robin P F; Bakker, Stephan J L.
  • Post A; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, 9700 RB, The Netherlands. Electronic address: a.post01@umcg.nl.
  • Dullaart RPF; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, 9700 RB, The Netherlands. Electronic address: dull.fam@12move.nl.
  • Bakker SJL; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, 9700 RB, The Netherlands. Electronic address: s.j.l.bakker@umcg.nl.
Virus Res ; 286: 198034, 2020 09.
Article in English | MEDLINE | ID: covidwho-348559
ABSTRACT
The angiotensin-converting enzyme 2 receptor (ACE2) is expressed in epithelial cells of many tissues including the kidney, and has been identified to interact with human pathogenic coronaviruses, including SARS-CoV-2. Although diffuse alveolar damage and acute respiratory failure are the main features of COVID-19 infection, two recent studies demonstrate that kidney impairment in hospitalized COVID-19 patients is common, and that kidney involvement is associated with high risk of in-hospital death. Interestingly, studies in rats have demonstrated that high dietary sodium intake results in down-regulation of the ACE2 expression in kidney tissue. We hypothesize that low sodium status makes kidney involvement during the course of COVID-19 infection more likely due to upregulation of membrane bound ACE2 in the kidneys. We propose that sodium intake and status should be monitored carefully during severe COVID-19 infections, and that low sodium intake be corrected early in its course, despite a potential conflict regarding common dietary recommendations to restrict dietary sodium intake in patients with hypertension, diabetes, and kidney disease.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Sodium, Dietary / Coronavirus Infections / Peptidyl-Dipeptidase A / Spike Glycoprotein, Coronavirus / Betacoronavirus / Kidney Type of study: Prognostic study Language: English Journal: Virus Res Journal subject: Virology Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Sodium, Dietary / Coronavirus Infections / Peptidyl-Dipeptidase A / Spike Glycoprotein, Coronavirus / Betacoronavirus / Kidney Type of study: Prognostic study Language: English Journal: Virus Res Journal subject: Virology Year: 2020 Document Type: Article