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Infection and Rapid Transmission of SARS-CoV-2 in Ferrets.
Kim, Young-Il; Kim, Seong-Gyu; Kim, Se-Mi; Kim, Eun-Ha; Park, Su-Jin; Yu, Kwang-Min; Chang, Jae-Hyung; Kim, Eun Ji; Lee, Seunghun; Casel, Mark Anthony B; Um, Jihye; Song, Min-Suk; Jeong, Hye Won; Lai, Van Dam; Kim, Yeonjae; Chin, Bum Sik; Park, Jun-Sun; Chung, Ki-Hyun; Foo, Suan-Sin; Poo, Haryoung; Mo, In-Pil; Lee, Ok-Jun; Webby, Richard J; Jung, Jae U; Choi, Young Ki.
  • Kim YI; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Republic of Korea.
  • Kim SG; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.
  • Kim SM; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.
  • Kim EH; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Republic of Korea.
  • Park SJ; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Republic of Korea.
  • Yu KM; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Republic of Korea.
  • Chang JH; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.
  • Kim EJ; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.
  • Lee S; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.
  • Casel MAB; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Republic of Korea.
  • Um J; Research institute of Public Health, National Medical Center, Seoul, Republic of Korea.
  • Song MS; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Republic of Korea.
  • Jeong HW; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.
  • Lai VD; College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.
  • Kim Y; Research institute of Public Health, National Medical Center, Seoul, Republic of Korea.
  • Chin BS; Research institute of Public Health, National Medical Center, Seoul, Republic of Korea.
  • Park JS; Research institute of Public Health, National Medical Center, Seoul, Republic of Korea.
  • Chung KH; Research institute of Public Health, National Medical Center, Seoul, Republic of Korea.
  • Foo SS; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
  • Poo H; Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology, Daejeon, Republic of Korea.
  • Mo IP; College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.
  • Lee OJ; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea.
  • Webby RJ; Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Jung JU; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: jaeujung@med.usc.edu.
  • Choi YK; College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea; Zoonotic Infectious Diseases Research Center, Chungbuk National University, Cheongju, Republic of Korea. Electronic address: choiki55@chungbuk.ac.kr.
Cell Host Microbe ; 27(5): 704-709.e2, 2020 05 13.
Article in English | MEDLINE | ID: covidwho-34929
ABSTRACT
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in China and rapidly spread worldwide. To prevent SARS-CoV-2 dissemination, understanding the in vivo characteristics of SARS-CoV-2 is a high priority. We report a ferret model of SARS-CoV-2 infection and transmission that recapitulates aspects of human disease. SARS-CoV-2-infected ferrets exhibit elevated body temperatures and virus replication. Although fatalities were not observed, SARS-CoV-2-infected ferrets shed virus in nasal washes, saliva, urine, and feces up to 8 days post-infection. At 2 days post-contact, SARS-CoV-2 was detected in all naive direct contact ferrets. Furthermore, a few naive indirect contact ferrets were positive for viral RNA, suggesting airborne transmission. Viral antigens were detected in nasal turbinate, trachea, lungs, and intestine with acute bronchiolitis present in infected lungs. Thus, ferrets represent an infection and transmission animal model of COVID-19 that may facilitate development of SARS-CoV-2 therapeutics and vaccines.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Ferrets Topics: Vaccines Limits: Animals Language: English Journal: Cell Host Microbe Journal subject: Microbiology Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Ferrets Topics: Vaccines Limits: Animals Language: English Journal: Cell Host Microbe Journal subject: Microbiology Year: 2020 Document Type: Article