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COVID-19: beta-thalassemia subjects immunised?
Lansiaux, Edouard; Pébaÿ, Philippe Pierre; Picard, Jean-Laurent; Son-Forget, Joachim.
  • Lansiaux E; Henry Warembourg Medicine School, Lille University, 59000 Lille, France. Electronic address: edouard.lansiaux.etu@univ-lille.fr.
  • Pébaÿ PP; NexGen Analytics, 82801 Sheridan, WY, United States.
  • Picard JL; Conservatoire National des Arts et Métiers, 75141 Paris, France.
  • Son-Forget J; Assemblée Nationale, 75355 Paris, France.
Med Hypotheses ; 142: 109827, 2020 Sep.
Article in English | MEDLINE | ID: covidwho-352336
ABSTRACT
The novel coronavirus pneumonia (COVID-19) is a contagious acute respiratory infectious disease whose causative agent has been demonstrated to be a novel virus of the coronavirus family, SARSCoV-2. A recent PRE-print study has showed a heme attack on the 1-beta chain of hemoglobin by COVID19. Beta-thalassemia results of a default in the hemoglobin beta-chain synthesis. 1,5% global population are heterozygotes for this disease. In this study, by a multiple linear regression, we have analyzed the evolution of COVID-19 infection in three Italian regions (Puglia, Sardinia, Sicilia) with different beta-thalassemic prevalences, in order to search a link. The results have showed that betathalassemic heterozygote population prevalence is correlated to immunity against COVID-19, by a regression. This paper is only for academic discussion, the hypotheses and conclusions needs to be confirmed by further research.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Beta-Thalassemia / Coronavirus Infections Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Med Hypotheses Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Beta-Thalassemia / Coronavirus Infections Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Med Hypotheses Year: 2020 Document Type: Article