The G-Quadruplex/Helicase World as a Potential Antiviral Approach Against COVID-19.
Drugs
; 80(10): 941-946, 2020 Jul.
Article
in English
| MEDLINE | ID: covidwho-361231
ABSTRACT
G-Quadruplexes (G4s) are non-canonical secondary structures formed within guanine-rich regions of DNA or RNA. G4 sequences/structures have been detected in human and in viral genomes, including Coronaviruses Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2. Here, we outline the existing evidence indicating that G4 ligands and inhibitors of SARS-CoV-2 helicase may exert some antiviral activity reducing viral replication and can represent a potential therapeutic approach to tackle the COVID-19 pandemic due to SARS-CoV-2 infection. We also discuss how repositioning of FDA-approved drugs against helicase activity of other viruses, could represent a rapid strategy to limit deaths associated with COVID-19 pandemic.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Pneumonia, Viral
/
Genome, Viral
/
Coronavirus Infections
/
RNA Helicases
/
G-Quadruplexes
/
Betacoronavirus
Limits:
Humans
Language:
English
Journal:
Drugs
Year:
2020
Document Type:
Article
Affiliation country:
S40265-020-01321-z
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