SARS-CoV-2 spike glycoprotein-binding proteins expressed by upper respiratory tract bacteria may prevent severe viral infection.
FEBS Lett
; 594(11): 1651-1660, 2020 06.
Article
in English
| MEDLINE | ID: covidwho-361331
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a major global challenge. The virus infects host cells using its spike glycoprotein (S-protein) and has significantly higher infectivity and mortality rates among the aged population. Here, based on bioinformatic analysis, I provide evidence that some members of the upper respiratory tract (URT) commensal bacteria express viral S-protein -binding proteins. Based on this analysis and available data showing a decline in the population of these bacteria in the elderly, I propose that some URT commensal bacteria hamper SARS-CoV-2 infectivity and that a decline in the population of these bacteria contributes to the severity of infection. Further studies should provide a better understanding of the interaction of URT bacteria and SARS-CoV-2, which may lead to new therapeutic approaches.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Respiratory System
/
Bacterial Proteins
/
Microbial Interactions
/
Spike Glycoprotein, Coronavirus
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
FEBS Lett
Year:
2020
Document Type:
Article
Affiliation country:
1873-3468.13845
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