Your browser doesn't support javascript.
Lipid-Protein and Protein-Protein Interactions in the Pulmonary Surfactant System and Their Role in Lung Homeostasis.
Cañadas, Olga; Olmeda, Bárbara; Alonso, Alejandro; Pérez-Gil, Jesús.
  • Cañadas O; Departament of Biochemistry and Molecular Biology, Faculty of Biology, Complutense University, 28040 Madrid, Spain.
  • Olmeda B; Research Institut "Hospital Doce de Octubre (imasdoce)", 28040 Madrid, Spain.
  • Alonso A; Departament of Biochemistry and Molecular Biology, Faculty of Biology, Complutense University, 28040 Madrid, Spain.
  • Pérez-Gil J; Research Institut "Hospital Doce de Octubre (imasdoce)", 28040 Madrid, Spain.
Int J Mol Sci ; 21(10)2020 May 25.
Article in English | MEDLINE | ID: covidwho-361420
ABSTRACT
Pulmonary surfactant is a lipid/protein complex synthesized by the alveolar epithelium and secreted into the airspaces, where it coats and protects the large respiratory air-liquid interface. Surfactant, assembled as a complex network of membranous structures, integrates elements in charge of reducing surface tension to a minimum along the breathing cycle, thus maintaining a large surface open to gas exchange and also protecting the lung and the body from the entrance of a myriad of potentially pathogenic entities. Different molecules in the surfactant establish a multivalent crosstalk with the epithelium, the immune system and the lung microbiota, constituting a crucial platform to sustain homeostasis, under health and disease. This review summarizes some of the most important molecules and interactions within lung surfactant and how multiple lipid-protein and protein-protein interactions contribute to the proper maintenance of an operative respiratory surface.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Surfactant-Associated Proteins / Alveolar Epithelial Cells / Homeostasis Limits: Animals / Humans Language: English Year: 2020 Document Type: Article Affiliation country: Ijms21103708

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Surfactant-Associated Proteins / Alveolar Epithelial Cells / Homeostasis Limits: Animals / Humans Language: English Year: 2020 Document Type: Article Affiliation country: Ijms21103708