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Repurposing Quaternary Ammonium Compounds as Potential Treatments for COVID-19.
Baker, Nancy; Williams, Antony J; Tropsha, Alexander; Ekins, Sean.
  • Baker N; Leidos, Research Triangle Park, Durham, North Carolina, USA.
  • Williams AJ; Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency (U.S. EPA), Research Triangle Park, Durham, North Carolina, USA.
  • Tropsha A; Laboratory for Molecular Modeling, UNC Eshelman School of Pharmacy, UNC Chapel Hill, Chapel Hill, North Carolina, 27599, USA.
  • Ekins S; Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina, 27606, USA. sean@collaborationspharma.com.
Pharm Res ; 37(6): 104, 2020 May 25.
Article in English | MEDLINE | ID: covidwho-361503
ABSTRACT
The COVID-19 pandemic has highlighted an important role for drug repurposing. Quaternary ammonium compounds such as ammonium chloride, cetylpyridinium and miramistin represent widely accessible antiseptic molecules with well-known broad-spectrum antiviral activities and represent a repurposing opportunity as therapeutics against SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Drug Repositioning / Pandemics / Betacoronavirus / Quaternary Ammonium Compounds / Anti-Infective Agents, Local Limits: Humans Language: English Journal: Pharm Res Year: 2020 Document Type: Article Affiliation country: S11095-020-02842-8

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Drug Repositioning / Pandemics / Betacoronavirus / Quaternary Ammonium Compounds / Anti-Infective Agents, Local Limits: Humans Language: English Journal: Pharm Res Year: 2020 Document Type: Article Affiliation country: S11095-020-02842-8