Long-term clinical outcomes in survivors of severe acute respiratory syndrome and Middle East respiratory syndrome coronavirus outbreaks after hospitalisation or ICU admission: A systematic review and meta-analysis.
J Rehabil Med
; 52(5): jrm00063, 2020 05 31.
Article
in English
| MEDLINE | ID: covidwho-361524
ABSTRACT
OBJECTIVE:
To determine long-term clinical outcomes in survivors of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronavirus infections after hospitalization or intensive care unit admission. DATA SOURCES Ovid MEDLINE, EMBASE, CINAHL Plus, and PsycINFO were searched. STUDY SELECTION Original studies reporting clinical outcomes of adult SARS and MERS survivors 3 months after admission or 2 months after discharge were included. DATA EXTRACTION Studies were graded using the Oxford Centre for Evidence-Based Medicine 2009 Level of Evidence Tool. Meta-analysis was used to derive pooled estimates for prevalence/severity of outcomes up to 6 months after hospital discharge, and beyond 6 months after discharge. DATASYNTHESIS:
Of 1,169 identified studies, 28 were included in the analysis. Pooled analysis revealed that common complications up to 6 months after discharge were impaired diffusing capacity for carbon monoxide (prevalence 27%, 95% confidence interval (CI) 1545%); and reduced exercise capacity (mean 6-min walking distance 461 m, CI 450473 m). The prevalences of post-traumatic stress disorder (39%, 95% CI 3147%), depression (33%, 95% CI 2050%) and anxiety (30%, 95% CI 1061) beyond 6 months after discharge were considerable. Low scores on Short-Form 36 were identified beyond 6 months after discharge.CONCLUSION:
Lung function abnormalities, psychological impairment and reduced exercise capacity were common in SARS and MERS survivors. Clinicians should anticipate and investigate similar long-term outcomes in COVID-19 survivors.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Coronavirus Infections
/
Severe Acute Respiratory Syndrome
/
Middle East Respiratory Syndrome Coronavirus
Type of study:
Observational study
/
Prognostic study
/
Reviews
/
Systematic review/Meta Analysis
Topics:
Long Covid
Limits:
Adult
/
Humans
Language:
English
Journal:
J Rehabil Med
Journal subject:
Rehabilitation
Year:
2020
Document Type:
Article
Affiliation country:
16501977-2694
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