Implications for Neuromodulation Therapy to Control Inflammation and Related Organ Dysfunction in COVID-19.
J Cardiovasc Transl Res
; 13(6): 894-899, 2020 12.
Article
in English
| MEDLINE | ID: covidwho-378267
ABSTRACT
COVID-19 is a syndrome that includes more than just isolated respiratory disease, as severe acute respiratory syndrome-coronavirus 2 (SARS-CoV2) also interacts with the cardiovascular, nervous, renal, and immune system at multiple levels, increasing morbidity in patients with underlying cardiometabolic conditions and inducing myocardial injury or dysfunction. Emerging evidence suggests that patients with the highest rate of morbidity and mortality following SARS-CoV2 infection have also developed a hyperinflammatory syndrome (also termed cytokine release syndrome). We lay out the potential contribution of a dysfunction in autonomic tone to the cytokine release syndrome and related multiorgan damage in COVID-19. We hypothesize that a cholinergic anti-inflammatory pathway could be targeted as a therapeutic avenue. Graphical Abstract .
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Cholinergic Fibers
/
Vagus Nerve Stimulation
/
Cytokine Release Syndrome
/
SARS-CoV-2
/
COVID-19
/
COVID-19 Drug Treatment
/
Inflammation
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
J Cardiovasc Transl Res
Journal subject:
Vascular Diseases
/
Cardiology
Year:
2020
Document Type:
Article
Affiliation country:
S12265-020-10031-6
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