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Expert recommendations on blood purification treatment protocol for patients with severe COVID-19.
Yang, Xiang-Hong; Sun, Ren-Hua; Zhao, Ming-Yan; Chen, Er-Zhen; Liu, Jiao; Wang, Hong-Liang; Yang, Rong-Li; Chen, De-Chang.
  • Yang XH; Department of Critical Care Medicine, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, China.
  • Sun RH; Department of Critical Care Medicine, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, China.
  • Zhao MY; Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China.
  • Chen EZ; Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • Liu J; Department of Critical Care Medicine, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai 201800, China.
  • Wang HL; Department of Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China.
  • Yang RL; Department of Critical Care Medicine, Dalian Municipal Central Hospital, Dalian, Liaoning 116033, China.
  • Chen DC; Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Chronic Dis Transl Med ; 6(2): 106-114, 2020 Jun.
Article in English | MEDLINE | ID: covidwho-379972
Semantic information from SemMedBD (by NLM)
1. Severe disorder PROCESS_OF Patients
Subject
Severe disorder
Predicate
PROCESS_OF
Object
Patients
2. Severe Acute Respiratory Syndrome PROCESS_OF Patients
Subject
Severe Acute Respiratory Syndrome
Predicate
PROCESS_OF
Object
Patients
3. Middle East Respiratory Syndrome PROCESS_OF Patients
Subject
Middle East Respiratory Syndrome
Predicate
PROCESS_OF
Object
Patients
4. Blood Treatment TREATS Disease
Subject
Blood Treatment
Predicate
TREATS
Object
Disease
5. Disease PROCESS_OF Patients
Subject
Disease
Predicate
PROCESS_OF
Object
Patients
6. Blood Treatment TREATS Patients
Subject
Blood Treatment
Predicate
TREATS
Object
Patients
7. Severe disorder PROCESS_OF Patients
Subject
Severe disorder
Predicate
PROCESS_OF
Object
Patients
8. Severe Acute Respiratory Syndrome PROCESS_OF Patients
Subject
Severe Acute Respiratory Syndrome
Predicate
PROCESS_OF
Object
Patients
9. Middle East Respiratory Syndrome PROCESS_OF Patients
Subject
Middle East Respiratory Syndrome
Predicate
PROCESS_OF
Object
Patients
10. Blood Treatment TREATS Disease
Subject
Blood Treatment
Predicate
TREATS
Object
Disease
11. Disease PROCESS_OF Patients
Subject
Disease
Predicate
PROCESS_OF
Object
Patients
12. Blood Treatment TREATS Patients
Subject
Blood Treatment
Predicate
TREATS
Object
Patients
ABSTRACT
Coronavirus disease (COVID-19) was first diagnosed in Wuhan in December 2019. The World Health Organization defined the subsequent outbreak of COVID-19 worldwide as a public health emergency of international concern. Epidemiological data indicate that at least 20% of COVID-19 patients have severe disease. In addition to impairment of the respiratory system, acute kidney injury (AKI) is a major complication. Immune damage mediated by cytokine storms and concomitant AKI is a key factor for poor prognosis. Based on previous experience of blood purification for patients with severe acute respiratory syndrome and Middle East respiratory syndrome combined with clinical front-line practice, we developed a blood purification protocol for patients with severe COVID-19. This protocol is divided into four major steps. The first step is to assess whether patients with severe COVID-19 require blood purification. The second step is to prescribe a blood purification treatment for patients with COVID-19. The third step is to monitor and adjust parameters of blood purification. The fourth step is to evaluate the timing of discontinuation of blood purification. It is expected that blood purification will play a key role in effectively reducing the mortality of patients with severe COVID-19 through the standardized implementation of the present protocol.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Language: English Journal: Chronic Dis Transl Med Year: 2020 Document Type: Article Affiliation country: J.cdtm.2020.04.002

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Language: English Journal: Chronic Dis Transl Med Year: 2020 Document Type: Article Affiliation country: J.cdtm.2020.04.002