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Extracorporeal Blood Purification and Organ Support in the Critically Ill Patient during COVID-19 Pandemic: Expert Review and Recommendation.
Ronco, Claudio; Bagshaw, Sean M; Bellomo, Rinaldo; Clark, William R; Husain-Syed, Faeq; Kellum, John A; Ricci, Zaccaria; Rimmelé, Thomas; Reis, Thiago; Ostermann, Marlies.
  • Ronco C; Department of Nephrology, University of Padova, Padova, Italy.
  • Bagshaw SM; International Renal Research Institute (IRRIV), San Bortolo Hospital, Vicenza, Italy.
  • Bellomo R; Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
  • Clark WR; Centre for Integrated Critical Care, The University of Melbourne, Melbourne, Victoria, Australia.
  • Husain-Syed F; Department of Intensive Care, Austin Hospital, Melbourne, Victoria, Australia.
  • Kellum JA; Davidson School of Chemical Engineering, Purdue University, West Lafayette, Indiana, USA.
  • Ricci Z; Department of Internal Medicine II, Division of Nephrology, Pulmonology and Critical Care Medicine, University Hospital Giessen and Marburg, Giessen, Germany.
  • Rimmelé T; Department of Critical Care Medicine, Center for Critical Care Nephrology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Reis T; Center for Critical Care Nephrology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Ostermann M; Department of Cardiology and Cardiac Surgery, Pediatric Cardiac Intensive Care Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Blood Purif ; 50(1): 17-27, 2021.
Article in English | MEDLINE | ID: covidwho-381787
ABSTRACT
Critically ill COVID-19 patients are generally admitted to the ICU for respiratory insufficiency which can evolve into a multiple-organ dysfunction syndrome requiring extracorporeal organ support. Ongoing advances in technology and science and progress in information technology support the development of integrated multi-organ support platforms for personalized treatment according to the changing needs of the patient. Based on pathophysiological derangements observed in COVID-19 patients, a rationale emerges for sequential extracorporeal therapies designed to remove inflammatory mediators and support different organ systems. In the absence of vaccines or direct therapy for COVID-19, extracorporeal therapies could represent an option to prevent organ failure and improve survival. The enormous demand in care for COVID-19 patients requires an immediate response from the scientific community. Thus, a detailed review of the available technology is provided by experts followed by a series of recommendation based on current experience and opinions, while waiting for generation of robust evidence from trials.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Extracorporeal Membrane Oxygenation / Hemoperfusion / Critical Illness / Continuous Renal Replacement Therapy / COVID-19 / Multiple Organ Failure Type of study: Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Blood Purif Year: 2021 Document Type: Article Affiliation country: 000508125

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Extracorporeal Membrane Oxygenation / Hemoperfusion / Critical Illness / Continuous Renal Replacement Therapy / COVID-19 / Multiple Organ Failure Type of study: Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Blood Purif Year: 2021 Document Type: Article Affiliation country: 000508125