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Treatments Administered to the First 9152 Reported Cases of COVID-19: A Systematic Review.
Fajgenbaum, David C; Khor, Johnson S; Gorzewski, Alexander; Tamakloe, Mark-Avery; Powers, Victoria; Kakkis, Joseph J; Repasky, Mileva; Taylor, Anne; Beschloss, Alexander; Hernandez-Miyares, Laura; Go, Beatrice; Nimgaonkar, Vivek; McCarthy, Madison S; Kim, Casey J; Pai, Ruth-Anne Langan; Frankl, Sarah; Angelides, Philip; Jiang, Joanna; Rasheed, Rozena; Napier, Erin; Mackay, Duncan; Pierson, Sheila K.
  • Fajgenbaum DC; Department of Medicine, Division of Translational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. davidfa@pennmedicine.upenn.edu.
  • Khor JS; Department of Medicine, Division of Translational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Gorzewski A; Department of Medicine, Division of Translational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Tamakloe MA; Department of Medicine, Division of Translational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Powers V; Department of Medicine, Division of Translational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Kakkis JJ; University of Pennsylvania, Philadelphia, PA, USA.
  • Repasky M; Castleman Disease Collaborative Network, Philadelphia, PA, USA.
  • Taylor A; The Ohio State University College of Medicine, Columbus, OH, USA.
  • Beschloss A; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Hernandez-Miyares L; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Go B; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Nimgaonkar V; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • McCarthy MS; Brown University, Providence, RI, USA.
  • Kim CJ; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Pai RL; Department of Medicine, Division of Translational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Frankl S; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Angelides P; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Jiang J; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Rasheed R; Department of Medicine, Division of Translational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Napier E; John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
  • Mackay D; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Pierson SK; Department of Medicine, Division of Translational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Infect Dis Ther ; 9(3): 435-449, 2020 Sep.
Article in English | MEDLINE | ID: covidwho-381948
Preprint
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Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. Therapeutic procedure ADMINISTERED_TO Patients
Subject
Therapeutic procedure
Predicate
ADMINISTERED_TO
Object
Patients
3. Therapeutic procedure TREATS COVID-19
Subject
Therapeutic procedure
Predicate
TREATS
Object
COVID-19
4. Therapeutic procedure TREATS Patients
Subject
Therapeutic procedure
Predicate
TREATS
Object
Patients
5. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
6. Therapeutic procedure ADMINISTERED_TO Patients
Subject
Therapeutic procedure
Predicate
ADMINISTERED_TO
Object
Patients
7. Therapeutic procedure TREATS COVID-19
Subject
Therapeutic procedure
Predicate
TREATS
Object
COVID-19
8. Therapeutic procedure TREATS Patients
Subject
Therapeutic procedure
Predicate
TREATS
Object
Patients
ABSTRACT
The emergence of SARS-CoV-2/2019 novel coronavirus (COVID-19) has created a global pandemic with no approved treatments or vaccines. Many treatments have already been administered to COVID-19 patients but have not been systematically evaluated. We performed a systematic literature review to identify all treatments reported to be administered to COVID-19 patients and to assess time to clinically meaningful response for treatments with sufficient data. We searched PubMed, BioRxiv, MedRxiv, and ChinaXiv for articles reporting treatments for COVID-19 patients published between 1 December 2019 and 27 March 2020. Data were analyzed descriptively. Of the 2706 articles identified, 155 studies met the inclusion criteria, comprising 9152 patients. The cohort was 45.4% female and 98.3% hospitalized, and mean (SD) age was 44.4 years (SD 21.0). The most frequently administered drug classes were antivirals, antibiotics, and corticosteroids, and of the 115 reported drugs, the most frequently administered was combination lopinavir/ritonavir, which was associated with a time to clinically meaningful response (complete symptom resolution or hospital discharge) of 11.7 (1.09) days. There were insufficient data to compare across treatments. Many treatments have been administered to the first 9152 reported cases of COVID-19. These data serve as the basis for an open-source registry of all reported treatments given to COVID-19 patients at www.CDCN.org/CORONA . Further work is needed to prioritize drugs for investigation in well-controlled clinical trials and treatment protocols.
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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Type of study: Prognostic study / Systematic review Language: English Journal: Infect Dis Ther Clinical aspect: Etiology Year: 2020

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Type of study: Prognostic study / Systematic review Language: English Journal: Infect Dis Ther Clinical aspect: Etiology Year: 2020
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