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A systematic review on COVID-19: urological manifestations, viral RNA detection and special considerations in urological conditions.
Chan, Vinson Wai-Shun; Chiu, Peter Ka-Fung; Yee, Chi-Hang; Yuan, Yuhong; Ng, Chi-Fai; Teoh, Jeremy Yuen-Chun.
  • Chan VW; School of Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, UK.
  • Chiu PK; S.H. Ho Urology Centre, Department of Surgery, 4/F LCW Clinical Sciences Building, Prince of Wales Hospital, The Chinese University of Hong Kong, 30-32 Ngan Shing Street, Shatin, New Territories, Hong Kong, China.
  • Yee CH; S.H. Ho Urology Centre, Department of Surgery, 4/F LCW Clinical Sciences Building, Prince of Wales Hospital, The Chinese University of Hong Kong, 30-32 Ngan Shing Street, Shatin, New Territories, Hong Kong, China.
  • Yuan Y; Department of Medicine, McMaster University, Hamilton, Canada.
  • Ng CF; S.H. Ho Urology Centre, Department of Surgery, 4/F LCW Clinical Sciences Building, Prince of Wales Hospital, The Chinese University of Hong Kong, 30-32 Ngan Shing Street, Shatin, New Territories, Hong Kong, China.
  • Teoh JY; S.H. Ho Urology Centre, Department of Surgery, 4/F LCW Clinical Sciences Building, Prince of Wales Hospital, The Chinese University of Hong Kong, 30-32 Ngan Shing Street, Shatin, New Territories, Hong Kong, China. jeremyteoh@surgery.cuhk.edu.hk.
World J Urol ; 39(9): 3127-3138, 2021 Sep.
Article in English | MEDLINE | ID: covidwho-381965
ABSTRACT
PURPOSE AND

OBJECTIVE:

We performed a systematic review on COVID-19 and its potential urological manifestations.

METHODS:

A literature search was performed using combination of keywords (MeSH terms and free text words) relating to COVID-19, urology, faeces and stool on multiple databases. Primary outcomes were the urological manifestations of COVID-19, and SARS-CoV-2 viral RNA detection in urine and stool samples. Meta-analyses were performed when there were two or more studies reporting on the same outcome. Special considerations in urological conditions that were relevant in the pandemic of COVID-19 were reported in a narrative manner.

RESULTS:

There were a total of 21 studies with 3714 COVID-19 patients, and urinary symptoms were absent in all of them. In patients with COVID-19, 7.58% (95% CI 3.30-13.54%) developed acute kidney injury with a mortality rate of 93.27% (95% CI 81.46-100%) amongst them. 5.74% (95% CI 2.88-9.44%) of COVID-19 patients had positive viral RNA in urine samples, but the duration of viral shedding in urine was unknown. 65.82% (95% CI 45.71-83.51%) of COVID-19 patients had positive viral RNA in stool samples, which were detected from 2 to 47 days from symptom onset. 31.6% of renal transplant recipients with COVID-19 required non-invasive ventilation, and the overall mortality rate was 15.4%.

CONCLUSIONS:

Acute kidney injury leading to mortality is common amongst COVID-19 patients, likely as a result of direct viral toxicity. Viral RNA positivity was detected in both urine and stool samples, so precautions are needed when we perform transurethral or transrectal procedures.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Urologic Diseases / Acute Kidney Injury / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: World J Urol Year: 2021 Document Type: Article Affiliation country: S00345-020-03246-4

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Urologic Diseases / Acute Kidney Injury / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: World J Urol Year: 2021 Document Type: Article Affiliation country: S00345-020-03246-4