Lymphopenia in COVID-19: Therapeutic opportunities.
Cell Biol Int
; 44(9): 1792-1797, 2020 Sep.
Article
in English
| MEDLINE | ID: covidwho-382103
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is uncontrollably spread all over the world. The host immune responses strongly try to confront it with all the potential cells and cytokines. With chronically condition of SARS-CoV-2, natural killer cells and T cells become exhausted and decreasing their count leads to lymphopenia. Inability to eradicate the infected organ makes hyperinitiation of the immune system, which releases the excessive inflammatory cytokines to compensate the exhausted one as well as the low lymphocytes counts; it consequently leads to the cytokine storm syndrome. These mechanisms and the potential therapeutic targeting are discussed in this paper.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Coronavirus Infections
/
Betacoronavirus
/
Lymphopenia
Type of study:
Observational study
Limits:
Humans
Language:
English
Journal:
Cell Biol Int
Year:
2020
Document Type:
Article
Affiliation country:
Cbin.11403
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