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Lymphopenia in COVID-19: Therapeutic opportunities.
Fathi, Nazanin; Rezaei, Nima.
  • Fathi N; Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Rezaei N; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Cell Biol Int ; 44(9): 1792-1797, 2020 Sep.
Article in English | MEDLINE | ID: covidwho-382103
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is uncontrollably spread all over the world. The host immune responses strongly try to confront it with all the potential cells and cytokines. With chronically condition of SARS-CoV-2, natural killer cells and T cells become exhausted and decreasing their count leads to lymphopenia. Inability to eradicate the infected organ makes hyperinitiation of the immune system, which releases the excessive inflammatory cytokines to compensate the exhausted one as well as the low lymphocytes counts; it consequently leads to the cytokine storm syndrome. These mechanisms and the potential therapeutic targeting are discussed in this paper.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Lymphopenia Type of study: Observational study Limits: Humans Language: English Journal: Cell Biol Int Year: 2020 Document Type: Article Affiliation country: Cbin.11403

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Lymphopenia Type of study: Observational study Limits: Humans Language: English Journal: Cell Biol Int Year: 2020 Document Type: Article Affiliation country: Cbin.11403