A possible strategy to fight COVID-19: Interfering with spike glycoprotein trimerization.
Biochem Biophys Res Commun
; 528(1): 35-38, 2020 07 12.
Article
in English
| MEDLINE | ID: covidwho-388951
ABSTRACT
The recent release of COVID-19 spike glycoprotein allows detailed analysis of the structural features that are required for stabilizing the infective form of its quaternary assembly. Trying to disassemble the trimeric structure of COVID-19 spike glycoprotein, we analyzed single protomer surfaces searching for concave moieties that are located at the three protomer-protomer interfaces. The presence of some druggable pockets at these interfaces suggested that some of the available drugs in Drug Bank could destabilize the quaternary spike glycoprotein formation by binding to these pockets, therefore interfering with COVID-19 life cycle. The approach we propose here can be an additional strategy to fight against the deadly virus. Ligands of COVID-19 spike glycoprotein that we have predicted in the present computational investigation, might be the basis for new experimental studies in vitro and in vivo.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Coronavirus Infections
/
Drug Evaluation, Preclinical
/
Small Molecule Libraries
/
Protein Multimerization
/
Spike Glycoprotein, Coronavirus
/
Betacoronavirus
Type of study:
Observational study
/
Prognostic study
Topics:
Traditional medicine
Language:
English
Journal:
Biochem Biophys Res Commun
Year:
2020
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS