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The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design.
Deftereos, Spyridon G; Siasos, Gerasimos; Giannopoulos, Georgios; Vrachatis, Dimitrios A; Angelidis, Christos; Giotaki, Sotiria G; Gargalianos, Panagiotis; Giamarellou, Helen; Gogos, Charalampos; Daikos, Georgios; Lazanas, Marios; Lagiou, Pagona; Saroglou, Georgios; Sipsas, Nikolaos; Tsiodras, Sotirios; Chatzigeorgiou, Dimitrios; Moussas, Nikolaos; Kotanidou, Anastasia; Koulouris, Nikolaos; Oikonomou, Evangelos; Kaoukis, Andreas; Kossyvakis, Charalampos; Raisakis, Konstantinos; Fountoulaki, Katerina; Comis, Mihalis; Tsiachris, Dimitrios; Sarri, Eleni; Theodorakis, Andreas; Martinez-Dolz, Luis; Sanz-Sánchez, Jorge; Reimers, Bernhard; Stefanini, Giulio G; Cleman, Michael; Filippou, Dimitrios; Olympios, Christoforos D; Pyrgakis, Vlasios N; Goudevenos, John; Hahalis, George; Kolettis, Theofilos M; Iliodromitis, Efstathios; Tousoulis, Dimitrios; Stefanadis, Christodoulos.
  • Deftereos SG; Medical School, National & Kapodistrian University of Athens, Athens, Greece. Electronic address: spdeftereos@gmail.com.
  • Siasos G; Medical School, National & Kapodistrian University of Athens, Athens, Greece.
  • Giannopoulos G; General Hospital of Athens "G.Gennimatas" Hospital, Athens, Greece.
  • Vrachatis DA; Medical School, National & Kapodistrian University of Athens, Athens, Greece; Humanitas Clinical and Research Institute, Rozzano, Milan, Italy.
  • Angelidis C; Medical School, National & Kapodistrian University of Athens, Athens, Greece.
  • Giotaki SG; Medical School, National & Kapodistrian University of Athens, Athens, Greece.
  • Gargalianos P; Athens Medical Center, Athens, Greece.
  • Giamarellou H; Medical School, National & Kapodistrian University of Athens, Athens, Greece; Therapeutirion Hygeia, Athens, Greece.
  • Gogos C; Medical School, University of Patras, Patra, Greece.
  • Daikos G; Medical School, National & Kapodistrian University of Athens, Athens, Greece; Mitera Hospital, Athens, Greece.
  • Lazanas M; Metropolitan General Hospital, Athens, Greece.
  • Lagiou P; Medical School, National & Kapodistrian University of Athens, Athens, Greece.
  • Saroglou G; Medical School, National & Kapodistrian University of Athens, Athens, Greece; Metropolitan Hospital, Athens, Greece.
  • Sipsas N; Medical School, National & Kapodistrian University of Athens, Athens, Greece.
  • Tsiodras S; Medical School, National & Kapodistrian University of Athens, Athens, Greece.
  • Chatzigeorgiou D; Hellenic Air Force General Staff.
  • Moussas N; Athens Medical Center, Athens, Greece.
  • Kotanidou A; Medical School, National & Kapodistrian University of Athens, Athens, Greece.
  • Koulouris N; Medical School, National & Kapodistrian University of Athens, Athens, Greece.
  • Oikonomou E; Medical School, National & Kapodistrian University of Athens, Athens, Greece.
  • Kaoukis A; General Hospital of Athens "G.Gennimatas" Hospital, Athens, Greece.
  • Kossyvakis C; General Hospital of Athens "G.Gennimatas" Hospital, Athens, Greece.
  • Raisakis K; General Hospital of Athens "G.Gennimatas" Hospital, Athens, Greece.
  • Fountoulaki K; General Hospital of Elefsina "Thriasio", Elefsina, Greece.
  • Comis M; General Hospital of Elefsina "Thriasio", Elefsina, Greece.
  • Tsiachris D; Athens Medical Center, Athens, Greece.
  • Sarri E; Medical School, National & Kapodistrian University of Athens, Athens, Greece.
  • Theodorakis A; Missolonghi General Hospital "Chatzikosta", Missolonghi, Greece.
  • Martinez-Dolz L; Hospital Universitario y Politécnico La Fe, Valencia, Spain.
  • Sanz-Sánchez J; Humanitas Clinical and Research Institute, Rozzano, Milan, Italy; Hospital Universitario y Politécnico La Fe, Valencia, Spain.
  • Reimers B; Humanitas Clinical and Research Institute, Rozzano, Milan, Italy.
  • Stefanini GG; Humanitas Clinical and Research Institute, Rozzano, Milan, Italy.
  • Cleman M; Yale University School of Medicine, New Haven, CT, USA.
  • Filippou D; Medical School, National & Kapodistrian University of Athens, Athens, Greece.
  • Olympios CD; General Hospital of Elefsina "Thriasio", Elefsina, Greece.
  • Pyrgakis VN; General Hospital of Athens "G.Gennimatas" Hospital, Athens, Greece.
  • Goudevenos J; University of Ioannina, Ioannina, Greece.
  • Hahalis G; Medical School, University of Patras, Patra, Greece.
  • Kolettis TM; University of Ioannina, Ioannina, Greece.
  • Iliodromitis E; Medical School, National & Kapodistrian University of Athens, Athens, Greece.
  • Tousoulis D; Medical School, National & Kapodistrian University of Athens, Athens, Greece.
  • Stefanadis C; Medical School, National & Kapodistrian University of Athens, Athens, Greece; Athens Medical Center, Athens, Greece.
Hellenic J Cardiol ; 61(1): 42-45, 2020.
Article in English | MEDLINE | ID: covidwho-40673
ABSTRACT

OBJECTIVE:

Colchicine has been utilized safely in a variety of cardiovascular clinical conditions. Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19. GRECCO-19 will be a prospective, randomized, open-labeled, controlled study to assess the effects of colchicine in COVID-19 complications prevention.

METHODS:

Patients with laboratory confirmed SARS-CoV-2 infection (under RT PCR) and clinical picture that involves temperature >37.5 oC and at least two out of the i. sustained coughing, ii. sustained throat pain, iii. Anosmia and/or ageusia, iv. fatigue/tiredness, v. PaO2<95 mmHg will be included. Patients will be randomised (11) in colchicine or control group.

RESULTS:

Trial results will be disseminated through peer-reviewed publications and conference presentations.

CONCLUSION:

GRECCO-19 trial aims to identify whether colchicine may positively intervene in the clinical course of COVID-19. (ClinicalTrials.gov Identifier NCT04326790).
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Colchicine / Coronavirus Infections / Pandemics / Heart Diseases Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Language: English Journal: Hellenic J Cardiol Journal subject: Cardiology Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Colchicine / Coronavirus Infections / Pandemics / Heart Diseases Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Language: English Journal: Hellenic J Cardiol Journal subject: Cardiology Year: 2020 Document Type: Article