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Kidney Infarction in Patients With COVID-19.
Post, Adrian; den Deurwaarder, Edwin S G; Bakker, Stephan J L; de Haas, Robbert J; van Meurs, Matijs; Gansevoort, Ron T; Berger, Stefan P.
  • Post A; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Electronic address: a.post01@umcg.nl.
  • den Deurwaarder ESG; Department of Internal Medicine, Queen Beatrix Hospital, Winterswijk, the Netherlands.
  • Bakker SJL; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • de Haas RJ; Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • van Meurs M; Department of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • Gansevoort RT; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • Berger SP; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Am J Kidney Dis ; 76(3): 431-435, 2020 09.
Article in English | MEDLINE | ID: covidwho-436397
ABSTRACT
Coronavirus disease 2019 (COVID-19) is a contagious life-threatening infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Recent findings indicate an increased risk for acute kidney injury during COVID-19 infection. The pathophysiologic mechanisms leading to acute kidney injury in COVID-19 infection are unclear but may include direct cytopathic effects of the virus on kidney tubular and endothelial cells, indirect damage caused by virus-induced cytokine release, and kidney hypoperfusion due to a restrictive fluid strategy. In this report of 2 cases, we propose an additional pathophysiologic mechanism. We describe 2 cases in which patients with COVID-19 infection developed a decrease in kidney function due to kidney infarction. These patients did not have atrial fibrillation. One of these patients was treated with therapeutic doses of low-molecular-weight heparin, after which no further deterioration in kidney function was observed. Our findings implicate that the differential diagnosis of acute kidney injury in COVID-19-infected patients should include kidney infarction, which may have important preventive and therapeutic implications.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Acute Kidney Injury / Betacoronavirus / Infarction / Kidney Type of study: Case report / Diagnostic study / Prognostic study Topics: Long Covid Limits: Humans / Male / Middle aged Language: English Journal: Am J Kidney Dis Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Acute Kidney Injury / Betacoronavirus / Infarction / Kidney Type of study: Case report / Diagnostic study / Prognostic study Topics: Long Covid Limits: Humans / Male / Middle aged Language: English Journal: Am J Kidney Dis Year: 2020 Document Type: Article