Your browser doesn't support javascript.
Aberrant hyperactivation of cytotoxic T-cell as a potential determinant of COVID-19 severity.
Kang, Chang Kyung; Han, Gi-Chan; Kim, Minji; Kim, Gwanghun; Shin, Hyun Mu; Song, Kyoung-Ho; Choe, Pyoeng Gyun; Park, Wan Beom; Kim, Eu Suk; Kim, Hong Bin; Kim, Nam-Joong; Kim, Hang-Rae; Oh, Myoung-Don.
  • Kang CK; Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
  • Han GC; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Department of Anatomy & Cell Biology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; BK21 Plus Biomedical Science Project, Seoul National University C
  • Kim M; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Department of Anatomy & Cell Biology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; BK21 Plus Biomedical Science Project, Seoul National University C
  • Kim G; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Department of Anatomy & Cell Biology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; BK21 Plus Biomedical Science Project, Seoul National University C
  • Shin HM; Wide River Institute of Immunology, Seoul National University, Hongcheon 25159, Republic of Korea.
  • Song KH; Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea.
  • Choe PG; Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
  • Park WB; Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
  • Kim ES; Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea.
  • Kim HB; Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea.
  • Kim NJ; Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
  • Kim HR; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Department of Anatomy & Cell Biology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; BK21 Plus Biomedical Science Project, Seoul National University C
  • Oh MD; Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea. Electronic address: mdohmd@snu.ac.kr.
Int J Infect Dis ; 97: 313-321, 2020 Aug.
Article in English | MEDLINE | ID: covidwho-436630
ABSTRACT

OBJECTIVES:

We hypothesized that immune response may contribute to progression of coronavirus disease-19 (COVID-19) at the second week of illness. Therefore, we compared cell-mediated immune (CMI) responses between severe and mild COVID-19 cases.

METHODS:

We examined peripheral blood mononuclear cells of laboratory-confirmed COVID-19 patients from their first and third weeks of illness. Severe pneumonia was defined as an oxygen saturation ≤93% at room air. Expressions of molecules related to T-cell activation and functions were analyzed by flow cytometry.

RESULTS:

The population dynamics of T cells at the first week were not different between the two groups. However, total numbers of CD4+ and CD8+ T cells tended to be lower in the severe group at the third week of illness. Expressions of Ki-67, PD-1, perforin, and granzyme B in CD4+ or CD8+ T cells were significantly higher in the severe group than in the mild group at the third week. In contrast to the mild group, the levels of their expression did not decrease in the severe group.

CONCLUSIONS:

Severe COVID-19 had a higher degree of proliferation, activation, and cytotoxicity of T-cells at the late phase of illness without cytotoxic T-cell contraction, which might contribute to the development of severe COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Lymphocyte Activation / T-Lymphocytes, Cytotoxic / Coronavirus Infections / Immunity, Cellular Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Lymphocyte Activation / T-Lymphocytes, Cytotoxic / Coronavirus Infections / Immunity, Cellular Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article