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Altered COVID-19 receptor ACE2 expression in a higher risk group for cerebrovascular disease and ischemic stroke.
Choi, Ji-Young; Lee, Hye-Kyung; Park, Jung Hyun; Cho, Sun-Jung; Kwon, Munjin; Jo, Chulman; Koh, Young Ho.
  • Choi JY; Division of Brain Diseases, Center for Biomedical Sciences, Korea National Institute of Health, 187 Osongsaengmyeong 2-ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungcheongbuk-do, 28159, South Korea.
  • Lee HK; Division of Brain Diseases, Center for Biomedical Sciences, Korea National Institute of Health, 187 Osongsaengmyeong 2-ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungcheongbuk-do, 28159, South Korea.
  • Park JH; Division of Brain Diseases, Center for Biomedical Sciences, Korea National Institute of Health, 187 Osongsaengmyeong 2-ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungcheongbuk-do, 28159, South Korea.
  • Cho SJ; Division of Brain Diseases, Center for Biomedical Sciences, Korea National Institute of Health, 187 Osongsaengmyeong 2-ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungcheongbuk-do, 28159, South Korea.
  • Kwon M; Division of Brain Diseases, Center for Biomedical Sciences, Korea National Institute of Health, 187 Osongsaengmyeong 2-ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungcheongbuk-do, 28159, South Korea.
  • Jo C; Division of Brain Diseases, Center for Biomedical Sciences, Korea National Institute of Health, 187 Osongsaengmyeong 2-ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungcheongbuk-do, 28159, South Korea.
  • Koh YH; Division of Brain Diseases, Center for Biomedical Sciences, Korea National Institute of Health, 187 Osongsaengmyeong 2-ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungcheongbuk-do, 28159, South Korea. Electronic address: kohyh122@korea.kr.
Biochem Biophys Res Commun ; 528(3): 413-419, 2020 07 30.
Article in English | MEDLINE | ID: covidwho-436643
Semantic information from SemMedBD (by NLM)
1. receptor expression PROCESS_OF angiotensin converting enzyme 2
Subject
receptor expression
Predicate
PROCESS_OF
Object
angiotensin converting enzyme 2
2. receptor expression PROCESS_OF high-risk group
Subject
receptor expression
Predicate
PROCESS_OF
Object
high-risk group
3. Cerebrovascular accident PROCESS_OF Patients
Subject
Cerebrovascular accident
Predicate
PROCESS_OF
Object
Patients
4. Cerebrovascular accident PREDISPOSES Cerebrovascular Disorders
Subject
Cerebrovascular accident
Predicate
PREDISPOSES
Object
Cerebrovascular Disorders
5. Blood Vessel LOCATION_OF angiotensin converting enzyme 2
Subject
Blood Vessel
Predicate
LOCATION_OF
Object
angiotensin converting enzyme 2
6. Brain LOCATION_OF angiotensin converting enzyme 2
Subject
Brain
Predicate
LOCATION_OF
Object
angiotensin converting enzyme 2
7. Bark - plant part LOCATION_OF TSPAN33 gene|TSPAN33
Subject
Bark - plant part
Predicate
LOCATION_OF
Object
TSPAN33 gene|TSPAN33
8. angiotensin converting enzyme 2 STIMULATES TSPAN33 gene|TSPAN33
Subject
angiotensin converting enzyme 2
Predicate
STIMULATES
Object
TSPAN33 gene|TSPAN33
9. angiotensin converting enzyme 2 AUGMENTS Blood Vessel
Subject
angiotensin converting enzyme 2
Predicate
AUGMENTS
Object
Blood Vessel
10. angiotensin converting enzyme 2 AUGMENTS Brain
Subject
angiotensin converting enzyme 2
Predicate
AUGMENTS
Object
Brain
11. receptor expression PROCESS_OF angiotensin converting enzyme 2
Subject
receptor expression
Predicate
PROCESS_OF
Object
angiotensin converting enzyme 2
12. receptor expression PROCESS_OF high-risk group
Subject
receptor expression
Predicate
PROCESS_OF
Object
high-risk group
13. Cerebrovascular accident PROCESS_OF Patients
Subject
Cerebrovascular accident
Predicate
PROCESS_OF
Object
Patients
14. Cerebrovascular accident PREDISPOSES Cerebrovascular Disorders
Subject
Cerebrovascular accident
Predicate
PREDISPOSES
Object
Cerebrovascular Disorders
15. Blood Vessel LOCATION_OF angiotensin converting enzyme 2
Subject
Blood Vessel
Predicate
LOCATION_OF
Object
angiotensin converting enzyme 2
16. Brain LOCATION_OF angiotensin converting enzyme 2
Subject
Brain
Predicate
LOCATION_OF
Object
angiotensin converting enzyme 2
17. Bark - plant part LOCATION_OF TSPAN33 gene|TSPAN33
Subject
Bark - plant part
Predicate
LOCATION_OF
Object
TSPAN33 gene|TSPAN33
18. angiotensin converting enzyme 2 STIMULATES TSPAN33 gene|TSPAN33
Subject
angiotensin converting enzyme 2
Predicate
STIMULATES
Object
TSPAN33 gene|TSPAN33
19. angiotensin converting enzyme 2 AUGMENTS Blood Vessel
Subject
angiotensin converting enzyme 2
Predicate
AUGMENTS
Object
Blood Vessel
20. angiotensin converting enzyme 2 AUGMENTS Brain
Subject
angiotensin converting enzyme 2
Predicate
AUGMENTS
Object
Brain
ABSTRACT
Coronavirus disease 2019 (COVID-19) is a worldwide pandemic. It has a high transmission rate among humans, and is a threat to global public health. However, there are no effective prophylactics or therapeutics available. It is necessary to identify vulnerable and susceptible groups for adequate protection and care against this disease. Recent studies have reported that COVID-19 has angiotensin-converting enzyme 2 (ACE2) as a functional receptor, which may lead to the development of severe cerebrovascular diseases (CVD), including strokes, in patients with risk factors for CVD such as diabetes and smoking. Thus, the World Health Organization (WHO) advised caution against COVID-19 for smokers and patients with underlying clinical symptoms, including cardiovascular diseases. Here, we observed ACE2 expression in the brain of rat middle cerebral artery occlusion (MCAO) model and evaluated the effects of cigarette smoke extract (CSE) and diabetes on ACE2 expression in vessels. We showed that the levels of ACE2 expression was increased in the cortex penumbra after ischemic injuries. CSE treatment significantly elevated ACE2 expression in human brain vessels. We found that ACE2 expression was upregulated in primary cultured human blood vessels with diabetes compared to healthy controls. This study demonstrates that ACE2 expression is increased in ischemic brains and vessels exposed to diabetes or smoking, makes them vulnerable to COVID-19 infection.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Receptors, Virus / Brain / Up-Regulation / Brain Ischemia / Peptidyl-Dipeptidase A / Stroke / Diabetes Mellitus / Betacoronavirus / Smokers Type of study: Etiology study / Prognostic study / Randomized controlled trials / Risk factors Language: English Journal: Biochem Biophys Res Commun Year: 2020 Document Type: Article Affiliation country: J.bbrc.2020.05.203

Full text: Available Collection: International databases Database: MEDLINE Main subject: Receptors, Virus / Brain / Up-Regulation / Brain Ischemia / Peptidyl-Dipeptidase A / Stroke / Diabetes Mellitus / Betacoronavirus / Smokers Type of study: Etiology study / Prognostic study / Randomized controlled trials / Risk factors Language: English Journal: Biochem Biophys Res Commun Year: 2020 Document Type: Article Affiliation country: J.bbrc.2020.05.203