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Obesity is Associated with Worse Outcomes in COVID-19: Analysis of Early Data from New York City.
Hajifathalian, Kaveh; Kumar, Sonal; Newberry, Carolyn; Shah, Shawn; Fortune, Brett; Krisko, Tibor; Ortiz-Pujols, Shiara; Zhou, Xi Kathy; Dannenberg, Andrew J; Kumar, Rekha; Sharaiha, Reem Z.
  • Hajifathalian K; Division of Gastroenterology and Hepatology, New York-Presbyterian Hospital and Weill Cornell Medical Center, New York, New York, USA.
  • Kumar S; Division of Gastroenterology and Hepatology, New York-Presbyterian Hospital and Weill Cornell Medical Center, New York, New York, USA.
  • Newberry C; Division of Gastroenterology and Hepatology, New York-Presbyterian Hospital and Weill Cornell Medical Center, New York, New York, USA.
  • Shah S; Division of Gastroenterology and Hepatology, New York-Presbyterian Hospital and Weill Cornell Medical Center, New York, New York, USA.
  • Fortune B; Division of Gastroenterology and Hepatology, New York-Presbyterian Hospital and Weill Cornell Medical Center, New York, New York, USA.
  • Krisko T; Division of Gastroenterology and Hepatology, New York-Presbyterian Hospital and Weill Cornell Medical Center, New York, New York, USA.
  • Ortiz-Pujols S; Division of Endocrinology, New York-Presbyterian Hospital and Weill Cornell Medical Center, New York, New York, USA.
  • Zhou XK; Division of Biostatistics, New York-Presbyterian Hospital and Weill Cornell Medical Center, New York, New York, USA.
  • Dannenberg AJ; Division of Gastroenterology and Hepatology, New York-Presbyterian Hospital and Weill Cornell Medical Center, New York, New York, USA.
  • Kumar R; Division of Endocrinology, New York-Presbyterian Hospital and Weill Cornell Medical Center, New York, New York, USA.
  • Sharaiha RZ; Division of Gastroenterology and Hepatology, New York-Presbyterian Hospital and Weill Cornell Medical Center, New York, New York, USA.
Obesity (Silver Spring) ; 28(9): 1606-1612, 2020 09.
Article in English | MEDLINE | ID: covidwho-437469
ABSTRACT

OBJECTIVE:

The 2019 novel coronavirus disease (COVID-19) has triggered a rapidly expanding global pandemic in which patients exhibit a wide spectrum of disease severity. Given the high prevalence of obesity in the United States, we hypothesized that the presence of obesity may play a role in the clinical course of patients with COVID-19.

METHODS:

This is a retrospective review of adult patients admitted with confirmed severe acute respiratory syndrome coronavirus 2. Demographics, clinical characteristics, laboratory data, and clinical outcomes were abstracted. BMI (kilograms per meter squared) was analyzed with regard to a composite outcome of intensive care unit (ICU) admission or death and intubation rate.

RESULTS:

About 770 patients were included (61% male, mean age 63.5 years). Patients with obesity were more likely to present with fever, cough, and shortness of breath. Obesity was also associated with a significantly higher rate of ICU admission or death (RR = 1.58, P = 0.002) even after adjusting for age, race, and troponin level.

CONCLUSIONS:

Patients with obesity had an increased risk for critical illness leading to ICU admission or death compared with normal weight individuals. This study confirms that obesity is a major risk factor for COVID-19 disease severity, significantly impacting disease presentation and critical care requirements.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Obesity Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: Obesity (Silver Spring) Journal subject: Nutritional Sciences / Physiology / Metabolism Year: 2020 Document Type: Article Affiliation country: Oby.22923

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Obesity Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: Obesity (Silver Spring) Journal subject: Nutritional Sciences / Physiology / Metabolism Year: 2020 Document Type: Article Affiliation country: Oby.22923