The gendered impact of coronavirus disease (COVID-19): do estrogens play a role?
Eur J Contracept Reprod Health Care
; 25(3): 233-234, 2020 Jun.
Article
in English
| MEDLINE | ID: covidwho-437486
ABSTRACT
Objective:
Although sex-disaggregated data for COVID-19 show equal numbers of cases between men and women, there seem to be sex differences in mortality rate and vulnerability to the disease more men than women are dying.Methods:
We have explored the potential role of estrogens in this COVID-19 gendered impact.Results:
Estrogens stimulate the humoral response to viral infections, while testosterone and progesterone give an immune suppression of both innate and cell-mediated immune responses. We hypothesise that estrogens, in particular estradiol but also synthetic estrogen such as ethinylestradiol, could protect women from the most serious complications of COVID-19. The use of medications that keep hormonal levels high and stable, such as combined hormonal contraceptive, could therefore play a protective role. These potential benefits overtake the thrombotic risk in healthy women. As stated by the World Health Organization, all modern methods of contraception were safe to use during the COVID-19 pandemic.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Progesterone
/
Coronavirus Infections
/
Estrogens
/
Betacoronavirus
Type of study:
Experimental Studies
/
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Eur J Contracept Reprod Health Care
Journal subject:
Reproductive Medicine
/
Family Planning Services
Year:
2020
Document Type:
Article
Affiliation country:
13625187.2020.1766017
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