Combination of thrombolytic and immunosuppressive therapy for coronavirus disease 2019: A case report.
Int J Infect Dis
; 97: 90-93, 2020 Aug.
Article
in English
| MEDLINE | ID: covidwho-457203
ABSTRACT
In a proportion of patients, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a multisystem syndrome characterized by hyperinflammation, acute respiratory distress syndrome (ARDS), and hypercoagulability. A 68-year-old man with coronavirus disease 2019 (COVID-19) was admitted to the intensive care unit with respiratory failure, cytokine release syndrome (CRS), and skin ischemia - microthrombosis. Specific coagulation and inflammatory markers (D-dimer, ferritin, and C-reactive protein), along with the clinical picture, triggered the trial of recombinant tissue plasminogen activator (rt-PA) and tocilizumab. This was followed by resolution of the skin ischemia and CRS, while respiratory parameters improved. No major complications associated with rt-PA or tocilizumab occurred. The combination of rt-PA with targeted anti-inflammatory treatment could be a new therapeutic option for patients with COVID-19, ARDS, hyperinflammation, and increased blood viscosity.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Tissue Plasminogen Activator
/
Coronavirus Infections
/
Antibodies, Monoclonal, Humanized
/
Fibrinolytic Agents
/
Betacoronavirus
/
Immunosuppressive Agents
Type of study:
Case report
/
Prognostic study
/
Randomized controlled trials
Limits:
Aged
/
Humans
/
Male
Language:
English
Journal:
Int J Infect Dis
Journal subject:
Communicable Diseases
Year:
2020
Document Type:
Article
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