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Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors.
Han, Huan; Ma, Qingfeng; Li, Cong; Liu, Rui; Zhao, Li; Wang, Wei; Zhang, Pingan; Liu, Xinghui; Gao, Guosheng; Liu, Fang; Jiang, Yingan; Cheng, Xiaoming; Zhu, Chengliang; Xia, Yuchen.
  • Han H; Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.
  • Ma Q; Department of Clinical Laboratory, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
  • Li C; State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, School of Basic Medical Sciences, Wuhan University, Wuhan, People's Republic of China.
  • Liu R; Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.
  • Zhao L; State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, School of Basic Medical Sciences, Wuhan University, Wuhan, People's Republic of China.
  • Wang W; Department of Clinical Laboratory, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
  • Zhang P; Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.
  • Liu X; Department of Clinical Laboratory, Shanghai Gongli Hospital, the Second Military Medical University, Shanghai, People's Republic of China.
  • Gao G; Department of Clinical Laboratory, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, People's Republic of China.
  • Liu F; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.
  • Jiang Y; Department of Infectious Diseases, Renmin Hospital, Wuhan University, Wuhan, People's Republic of China.
  • Cheng X; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Zhu C; Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.
  • Xia Y; State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, School of Basic Medical Sciences, Wuhan University, Wuhan, People's Republic of China.
Emerg Microbes Infect ; 9(1): 1123-1130, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-457402
ABSTRACT
Since the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, it has rapidly spread across many other countries. While the majority of patients were considered mild, critically ill patients involving respiratory failure and multiple organ dysfunction syndrome are not uncommon, which could result death. We hypothesized that cytokine storm is associated with severe outcome. We enrolled 102 COVID-19 patients who were admitted to Renmin Hospital (Wuhan, China). All patients were classified into moderate, severe and critical groups according to their symptoms. 45 control samples of healthy volunteers were also included. Inflammatory cytokines and C-Reactive Protein (CRP) profiles of serum samples were analyzed by specific immunoassays. Results showed that COVID-19 patients have higher serum level of cytokines (TNF-α, IFN-γ, IL-2, IL-4, IL-6 and IL-10) and CRP than control individuals. Within COVID-19 patients, serum IL-6 and IL-10 levels are significantly higher in critical group (n = 17) than in moderate (n = 42) and severe (n = 43) group. The levels of IL-10 is positively correlated with CRP amount (r = 0.41, P < 0.01). Using univariate logistic regression analysis, IL-6 and IL-10 are found to be predictive of disease severity and receiver operating curve analysis could further confirm this result (AUC = 0.841, 0.822 respectively). Our result indicated higher levels of cytokine storm is associated with more severe disease development. Among them, IL-6 and IL-10 can be used as predictors for fast diagnosis of patients with higher risk of disease deterioration. Given the high levels of cytokines induced by SARS-CoV-2, treatment to reduce inflammation-related lung damage is critical.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Interleukin-6 / Interleukin-10 / Coronavirus Infections Type of study: Diagnostic study / Experimental Studies / Prognostic study / Randomized controlled trials Limits: Humans Country/Region as subject: Asia Language: English Journal: Emerg Microbes Infect Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Interleukin-6 / Interleukin-10 / Coronavirus Infections Type of study: Diagnostic study / Experimental Studies / Prognostic study / Randomized controlled trials Limits: Humans Country/Region as subject: Asia Language: English Journal: Emerg Microbes Infect Year: 2020 Document Type: Article