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Clinical outcomes and serologic response in solid organ transplant recipients with COVID-19: A case series from the United States.
Fung, Monica; Chiu, Charles Y; DeVoe, Catherine; Doernberg, Sarah B; Schwartz, Brian S; Langelier, Charles; Henrich, Timothy J; Yokoe, Deborah; Davis, John; Hays, Steven R; Chandran, Sindhu; Kukreja, Jasleen; Ng, Dianna; Prostko, John; Taylor, Russell; Reyes, Kevin; Bainbridge, Emma; Bond, Allison; Chin-Hong, Peter; Babik, Jennifer M.
  • Fung M; Division of Infectious Disease, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
  • Chiu CY; Division of Infectious Disease, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
  • DeVoe C; Department of Laboratory Medicine, University of California, San Francisco, California, USA.
  • Doernberg SB; UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, California, USA.
  • Schwartz BS; Division of Infectious Disease, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
  • Langelier C; Division of Infectious Disease, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
  • Henrich TJ; Division of Infectious Disease, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
  • Yokoe D; Division of Infectious Disease, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
  • Davis J; Chan Zuckerberg Biohub, San Francisco, California, USA.
  • Hays SR; Division of Infectious Disease, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
  • Chandran S; Division of Experimental Medicine, University of California San Francisco, San Francisco, California, USA.
  • Kukreja J; Division of Infectious Disease, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
  • Ng D; Division of Infectious Disease, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
  • Prostko J; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
  • Taylor R; Division of Nephrology, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
  • Reyes K; Division of Adult Cardiothoracic Surgery, Department of Surgery, University of California San Francisco, San Francisco, California, USA.
  • Bainbridge E; Department of Laboratory Medicine, University of California, San Francisco, California, USA.
  • Bond A; Abbott Laboratories, Inc., Abbott Park, Illinois, USA.
  • Chin-Hong P; Abbott Laboratories, Inc., Abbott Park, Illinois, USA.
  • Babik JM; Department of Laboratory Medicine, University of California, San Francisco, California, USA.
Am J Transplant ; 20(11): 3225-3233, 2020 11.
Article in English | MEDLINE | ID: covidwho-457438
ABSTRACT
The coronavirus disease 2019 (COVID-19) pandemic caused by SARS coronavirus 2 (SARS-CoV-2) has caused significant morbidity and mortality for patients and stressed healthcare systems worldwide. The clinical features, disease course, and serologic response of COVID-19 among immunosuppressed patients such as solid organ transplant (SOT) recipients, who are at presumed risk for more severe disease, are not well characterized. We describe our institutional experience with COVID-19 among 10 SOT patients, including the clinical presentation, treatment modalities, and outcomes of 7 renal transplant recipients, 1 liver transplant recipient, 1 heart transplant recipient, and 1 lung transplant recipient. In addition, we report the serologic response in SOT recipients, documenting a positive IgG response in all 7 hospitalized patients. We also review the existing literature on COVID-19 in SOT recipients to consolidate the current knowledge on COVID-19 in the SOT population for the transplant community.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Organ Transplantation / Immunocompromised Host / Pandemics / Transplant Recipients / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Case report / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: Am J Transplant Journal subject: Transplantation Year: 2020 Document Type: Article Affiliation country: Ajt.16079

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Organ Transplantation / Immunocompromised Host / Pandemics / Transplant Recipients / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Case report / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: Am J Transplant Journal subject: Transplantation Year: 2020 Document Type: Article Affiliation country: Ajt.16079