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Is Inhaled Furosemide a Potential Therapeutic for COVID-19?
Brennecke, Anja; Villar, Laura; Wang, Zhiyu; Doyle, Lisa M; Meek, Autumn; Reed, Mark; Barden, Christopher; Weaver, Donald F.
  • Brennecke A; Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.
  • Villar L; Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.
  • Wang Z; Krembil Research Institute, University Health Network, Toronto, Ontario, Canada; Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.
  • Doyle LM; Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.
  • Meek A; Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.
  • Reed M; Krembil Research Institute, University Health Network, Toronto, Ontario, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
  • Barden C; Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.
  • Weaver DF; Krembil Research Institute, University Health Network, Toronto, Ontario, Canada; Faculty of Medicine, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada. Electronic address: dweaver@uhnres.utoronto.ca.
Am J Med Sci ; 360(3): 216-221, 2020 09.
Article in English | MEDLINE | ID: covidwho-457538
ABSTRACT
The potentially lethal infection caused by the novel Severe Acute Respiratory Disease Coronavirus-2 (SARS-CoV-2) has evolved into a global crisis. Following the initial viral infection is the host inflammatory response that frequently results in excessive secretion of inflammatory cytokines (e.g., IL-6 and TNFα), developing into a self-targeting, toxic "cytokine storm" causing critical pulmonary tissue damage. The need for a therapeutic that is available immediately is growing daily but the de novo development of a vaccine may take years. Therefore, repurposing of approved drugs offers a promising approach to address this urgent need. Inhaled furosemide, a small molecule capable of inhibiting IL-6 and TNFα, may be an agent capable of treating the Coronavirus Disease 2019 cytokine storm in both resource-rich and developing countries. Furosemide is a "repurpose-able" small molecule therapeutics, that is safe, easily synthesized, handled, and stored, and is available in reasonable quantities worldwide.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Furosemide / Immunity, Innate Topics: Vaccines Limits: Humans Language: English Journal: Am J Med Sci Year: 2020 Document Type: Article Affiliation country: J.amjms.2020.05.044

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Furosemide / Immunity, Innate Topics: Vaccines Limits: Humans Language: English Journal: Am J Med Sci Year: 2020 Document Type: Article Affiliation country: J.amjms.2020.05.044