SARS-CoV-2 infection and overactivation of Nlrp3 inflammasome as a trigger of cytokine "storm" and risk factor for damage of hematopoietic stem cells.

Ratajczak, Mariusz Z; Kucia, Magda

Ratajczak, Mariusz Z; Kucia, Magda.

Ratajczak MZ; Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Kentucky, USA. mzrata01@louisville.edu.
Kucia M; Department of Regenerative Medicine, Center for Preclinical Research and Technology, Medical University of Warsaw, Warsaw, Poland. mzrata01@louisville.edu.

Leukemia ; 34(7): 1726-1729, 2020 07.

Article in English | MEDLINE | ID: covidwho-459385

ABSTRACT

ABSTRACT

The scientific community faces an unexpected and urgent challenge related to the SARS-CoV-2 pandemic and is investigating the role of receptors involved in entry of this virus into cells as well as pathomechanisms leading to a cytokine "storm," which in many cases ends in severe acute respiratory syndrome, fulminant myocarditis and kidney injury. An important question is if it may also damage hematopoietic stem progenitor cells?

Subject(s)

Coronavirus Infections/epidemiology; Cytokine Release Syndrome/epidemiology; Hematopoietic Stem Cells/virology; Inflammasomes/immunology; Pandemics; Pneumonia, Viral/epidemiology; Severe Acute Respiratory Syndrome/epidemiology; Acute Kidney Injury/epidemiology; Acute Kidney Injury/immunology; Acute Kidney Injury/prevention & control; Acute Kidney Injury/virology; Angiotensin-Converting Enzyme 2; Betacoronavirus/drug effects; Betacoronavirus/immunology; Betacoronavirus/pathogenicity; COVID-19; Coronavirus Infections/drug therapy; Coronavirus Infections/immunology; Coronavirus Infections/virology; Cytokine Release Syndrome/immunology; Cytokine Release Syndrome/prevention & control; Cytokine Release Syndrome/virology; Cytokines/antagonists & inhibitors; Cytokines/genetics; Cytokines/immunology; Furans/pharmacology; Gene Expression Regulation; Hematopoietic Stem Cells/drug effects; Hematopoietic Stem Cells/immunology; Heterocyclic Compounds, 4 or More Rings; Humans; Immunity, Innate/drug effects; Immunologic Factors/pharmacology; Indenes; Inflammasomes/antagonists & inhibitors; Inflammasomes/genetics; Myocarditis/epidemiology; Myocarditis/immunology; Myocarditis/prevention & control; Myocarditis/virology; NLR Family, Pyrin Domain-Containing 3 Protein/antagonists & inhibitors; NLR Family, Pyrin Domain-Containing 3 Protein/genetics; NLR Family, Pyrin Domain-Containing 3 Protein/immunology; Peptidyl-Dipeptidase A/genetics; Peptidyl-Dipeptidase A/immunology; Pneumonia, Viral/drug therapy; Pneumonia, Viral/immunology; Pneumonia, Viral/virology; Pyroptosis/drug effects; Pyroptosis/genetics; Pyroptosis/immunology; Risk Factors; SARS-CoV-2; Severe Acute Respiratory Syndrome/immunology; Severe Acute Respiratory Syndrome/prevention & control; Severe Acute Respiratory Syndrome/virology; Spike Glycoprotein, Coronavirus/genetics

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Hematopoietic Stem Cells / Coronavirus Infections / Severe Acute Respiratory Syndrome / Inflammasomes / Pandemics / Cytokine Release Syndrome Type of study: Observational study / Prognostic study Language: English Journal: Leukemia Journal subject: Hematology / Neoplasms Year: 2020 Document Type: Article Affiliation country: S41375-020-0887-9

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