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Malaria and Parasitic Neglected Tropical Diseases: Potential Syndemics with COVID-19?
Gutman, Julie R; Lucchi, Naomi W; Cantey, Paul T; Steinhardt, Laura C; Samuels, Aaron M; Kamb, Mary L; Kapella, Bryan K; McElroy, Peter D; Udhayakumar, Venkatachalam; Lindblade, Kim A.
  • Gutman JR; Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia.
  • Lucchi NW; Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia.
  • Cantey PT; Parasitic Diseases Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia.
  • Steinhardt LC; Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia.
  • Samuels AM; Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia.
  • Kamb ML; Parasitic Diseases Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia.
  • Kapella BK; U.S. President's Malaria Initiative, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia.
  • McElroy PD; Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia.
  • Udhayakumar V; Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia.
  • Lindblade KA; Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia.
Am J Trop Med Hyg ; 103(2): 572-577, 2020 08.
Article in English | MEDLINE | ID: covidwho-459519
Semantic information from SemMedBD (by NLM)
1. 2019 novel coronavirus CAUSES COVID-19
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
COVID-19
2. Storm NOS COEXISTS_WITH COVID-19
Subject
Storm NOS
Predicate
COEXISTS_WITH
Object
COVID-19
3. Malaria COEXISTS_WITH COVID-19
Subject
Malaria
Predicate
COEXISTS_WITH
Object
COVID-19
4. Neglected Diseases COEXISTS_WITH COVID-19
Subject
Neglected Diseases
Predicate
COEXISTS_WITH
Object
COVID-19
5. 2019 novel coronavirus CAUSES COVID-19
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
COVID-19
6. Storm NOS COEXISTS_WITH COVID-19
Subject
Storm NOS
Predicate
COEXISTS_WITH
Object
COVID-19
7. Malaria COEXISTS_WITH COVID-19
Subject
Malaria
Predicate
COEXISTS_WITH
Object
COVID-19
8. Neglected Diseases COEXISTS_WITH COVID-19
Subject
Neglected Diseases
Predicate
COEXISTS_WITH
Object
COVID-19
ABSTRACT
The COVID-19 pandemic, caused by SARS-CoV-2, have surpassed 5 million cases globally. Current models suggest that low- and middle-income countries (LMICs) will have a similar incidence but substantially lower mortality rate than high-income countries. However, malaria and neglected tropical diseases (NTDs) are prevalent in LMICs, and coinfections are likely. Both malaria and parasitic NTDs can alter immunologic responses to other infectious agents. Malaria can induce a cytokine storm and pro-coagulant state similar to that seen in severe COVID-19. Consequently, coinfections with malaria parasites and SARS-CoV-2 could result in substantially worse outcomes than mono-infections with either pathogen, and could shift the age pattern of severe COVID-19 to younger age-groups. Enhancing surveillance platforms could provide signals that indicate whether malaria, NTDs, and COVID-19 are syndemics (synergistic epidemics). Based on the prevalence of malaria and NTDs in specific localities, efforts to characterize COVID-19 in LMICs could be expanded by adding testing for malaria and NTDs. Such additional testing would allow the determination of the rates of coinfection and comparison of severity of outcomes by infection status, greatly improving the understanding of the epidemiology of COVID-19 in LMICs and potentially helping to mitigate its impact.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Parasitic Diseases / Pneumonia, Viral / Coronavirus Infections / Syndemic / Malaria Type of study: Observational study / Randomized controlled trials / Risk factors Limits: Humans Language: English Journal: Am J Trop Med Hyg Year: 2020 Document Type: Article Affiliation country: Ajtmh.20-0516

Full text: Available Collection: International databases Database: MEDLINE Main subject: Parasitic Diseases / Pneumonia, Viral / Coronavirus Infections / Syndemic / Malaria Type of study: Observational study / Randomized controlled trials / Risk factors Limits: Humans Language: English Journal: Am J Trop Med Hyg Year: 2020 Document Type: Article Affiliation country: Ajtmh.20-0516