A comprehensive analysis of genome composition and codon usage patterns of emerging coronaviruses.
Virus Res
; 283: 197976, 2020 07 02.
Article
in English
| MEDLINE | ID: covidwho-46070
ABSTRACT
An outbreak of atypical pneumonia caused by a novel Betacoronavirus (ßCoV), named SARS-CoV-2 has been declared a public health emergency of international concern by the World Health Organization. In order to gain insight into the emergence, evolution and adaptation of SARS-CoV-2 viruses, a comprehensive analysis of genome composition and codon usage of ßCoV circulating in China was performed. A biased nucleotide composition was found for SARS-CoV-2 genome. This bias in genomic composition is reflected in its codon and amino acid usage patterns. The overall codon usage in SARS-CoV-2 is similar among themselves and slightly biased. Most of the highly frequent codons are A- and U-ending, which strongly suggests that mutational bias is the main force shaping codon usage in this virus. Significant differences in relative synonymous codon usage frequencies among SARS-CoV-2 and human cells were found. These differences are due to codon usage preferences.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Gene Expression Regulation, Viral
/
Genome, Viral
/
Communicable Diseases, Emerging
/
Genomics
/
Betacoronavirus
/
Codon Usage
Type of study:
Observational study
Limits:
Animals
/
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Virus Res
Journal subject:
Virology
Year:
2020
Document Type:
Article
Affiliation country:
J.virusres.2020.197976
Similar
MEDLINE
...
LILACS
LIS