<i>TMPRSS2</i> and COVID-19: Serendipity or Opportunity for Intervention?

Stopsack, Konrad H; Mucci, Lorelei A; Antonarakis, Emmanuel S; Nelson, Peter S; Kantoff, Philip W

TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention?

Stopsack, Konrad H; Mucci, Lorelei A; Antonarakis, Emmanuel S; Nelson, Peter S; Kantoff, Philip W.

Stopsack KH; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Mucci LA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Antonarakis ES; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland.
Nelson PS; Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center and Department of Medicine, University of Washington, Seattle, Washington.
Kantoff PW; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. kantoff@mskcc.org.

Cancer Discov ; 10(6): 779-782, 2020 06.

Article in English | MEDLINE | ID: covidwho-46164

ABSTRACT

ABSTRACT

TMPRSS2 is both the most frequently altered gene in primary prostate cancer and a critical factor enabling cellular infection by coronaviruses, including SARS-CoV-2. The modulation of its expression by sex steroids could contribute to the male predominance of severe infections, and given that TMPRSS2 has no known indispensable functions, and inhibitors are available, it is an appealing target for prevention or treatment of respiratory viral infections.

Subject(s)

Betacoronavirus/drug effects; Coronavirus Infections/genetics; Pneumonia, Viral/genetics; Serine Endopeptidases/genetics; Serine Proteinase Inhibitors/pharmacology; COVID-19; Coronavirus Infections/drug therapy; Coronavirus Infections/mortality; Coronavirus Infections/prevention & control; Esters; Female; Gabexate/analogs & derivatives; Gabexate/pharmacology; Gene Expression Regulation; Genetic Predisposition to Disease; Guanidines; Humans; Influenza, Human/genetics; Male; Pandemics/prevention & control; Pneumonia, Viral/drug therapy; Pneumonia, Viral/mortality; Pneumonia, Viral/prevention & control; Prostatic Neoplasms/genetics; Prostatic Neoplasms/pathology; SARS-CoV-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Serine Endopeptidases / Serine Proteinase Inhibitors / Coronavirus Infections / Betacoronavirus Type of study: Experimental Studies / Prognostic study Limits: Female / Humans / Male Language: English Journal: Cancer Discov Year: 2020 Document Type: Article

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