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Benign COVID-19 in an immunocompromised cancer patient -  the case of a married couple.
Spezzani, Valentina; Piunno, Alessio; Iselin, Hans-Ulrich.
  • Spezzani V; Family Medicine, Unità Sanitaria Locale del Servizio Sanitario Regionale Emilia-Romagna, Modena, Italy.
  • Piunno A; Radiology, Ospedale di Sassuolo (Prov. Modena), Italy.
  • Iselin HU; Consultant for Interprofessional Communication, Riehen, Switzerland.
Swiss Med Wkly ; 150: w20246, 2020 04 06.
Article in English | MEDLINE | ID: covidwho-2285064
ABSTRACT
Respiratory failure in COVID-19 is a common feature in fatal cases and has been considered as a failure of the immune system to control the virus. Here we report the case of COVID-19 affecting an immunocompromised women and her presumably immunocompetent spouse. A married couple (age 60 years) was simultaneously admitted to the emergency department on 10 March 2020 because of dyspnoea and fever, consistent with COVID-19. The wife (patient 1) was partially immunocompromised as a consequence of a recently started chemotherapy with fulvestrant and abemaciclid for recurring breast cancer, her husband (patient 2) had been healthy except for a history of controlled arterial hypertension. Both patients were treated with darunavir/cobicistat and hydroxychloroquine. The clinical course of the immunocompromised partner was benign, without need of intensive care. She was able to leave the hospital on day 6 after admission. In contrast, her husband needed intensive care and his recovery was slow, although eventually successful too. These findings suggest that the course of COVID-19 is not necessarily ominous in the presence of a compromised immune response and tend to reinforce the emerging therapeutic concepts of a controlled mitigation of the immune cascade following SARS CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / Breast Neoplasms / Coronavirus Infections / Darunavir / Cobicistat / Hydroxychloroquine / Anti-Bacterial Agents Type of study: Case report / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Female / Humans / Male / Middle aged Language: English Journal: Swiss Med Wkly Journal subject: Medicine Year: 2020 Document Type: Article Affiliation country: Smw.2020.20246

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / Breast Neoplasms / Coronavirus Infections / Darunavir / Cobicistat / Hydroxychloroquine / Anti-Bacterial Agents Type of study: Case report / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Female / Humans / Male / Middle aged Language: English Journal: Swiss Med Wkly Journal subject: Medicine Year: 2020 Document Type: Article Affiliation country: Smw.2020.20246