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Assessing ACE2 expression patterns in lung tissues in the pathogenesis of COVID-19.
Li, Guoping; He, Xiang; Zhang, Lei; Ran, Qin; Wang, Junyi; Xiong, Anying; Wu, Dehong; Chen, Feng; Sun, Jinlyu; Chang, Christopher.
  • Li G; Chengdu Institute of Respiratory Health, Branch of National Clinical Research Center for Respiratory Disease, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, Chengdu, 610031, China; Laboratory of Allergy and Inflammation, The Third People's Hospital of C
  • He X; Chengdu Institute of Respiratory Health, Branch of National Clinical Research Center for Respiratory Disease, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, Chengdu, 610031, China; Laboratory of Allergy and Inflammation, The Third People's Hospital of C
  • Zhang L; Chengdu Institute of Respiratory Health, Branch of National Clinical Research Center for Respiratory Disease, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, Chengdu, 610031, China; Laboratory of Allergy and Inflammation, The Third People's Hospital of C
  • Ran Q; Chengdu Institute of Respiratory Health, Branch of National Clinical Research Center for Respiratory Disease, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, Chengdu, 610031, China; Laboratory of Allergy and Inflammation, The Third People's Hospital of C
  • Wang J; Chengdu Institute of Respiratory Health, Branch of National Clinical Research Center for Respiratory Disease, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, Chengdu, 610031, China; Laboratory of Allergy and Inflammation, The Third People's Hospital of C
  • Xiong A; Chengdu Institute of Respiratory Health, Branch of National Clinical Research Center for Respiratory Disease, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, Chengdu, 610031, China; Laboratory of Allergy and Inflammation, The Third People's Hospital of C
  • Wu D; Chengdu Institute of Respiratory Health, Branch of National Clinical Research Center for Respiratory Disease, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, Chengdu, 610031, China; Laboratory of Allergy and Inflammation, The Third People's Hospital of C
  • Chen F; Chengdu Institute of Respiratory Health, Branch of National Clinical Research Center for Respiratory Disease, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, Chengdu, 610031, China.
  • Sun J; Department of Allergy & Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, National Clinical Research Center for Immunologic Diseases, Beijing, 100730, China. Electronic address: sunjinlv@pumch.cn.
  • Chang C; Division of Pediatric Immunology and Allergy, Joe DiMaggio Children's Hospital, Hollywood, FL, 33021, USA; Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, CA, 95616, USA. Electronic address: chrchang@mhs.net.
J Autoimmun ; 112: 102463, 2020 08.
Article in English | MEDLINE | ID: covidwho-46938
ABSTRACT
It has been reported that SARS-CoV-2 may use ACE2 as a receptor to gain entry into human cells, in a way similar to that of SARS-CoV. Analyzing the distribution and expression level of ACE2 may therefore help reveal underlying mechanisms of viral susceptibility and post-infection modulation. In this study, we utilized previously uploaded information on ACE2 expression in various conditions including SARS-CoA to evaluate the role of ACE2 in SARS-CoV and extrapolate that to COVID-19. We found that the expression of ACE2 in healthy populations and patients with underlying diseases was not significantly different. However, based on the elevated expression of ACE2 in cigarette smokers, we speculate that long-term smoking may be a risk factor for COVID-19. Analysis of ACE2 in SARS-CoV infected cells suggests that ACE2 is not only a receptor but is also involved in post-infection regulation, including immune response, cytokine secretion, and viral genome replication. Moreover, we constructed Protein-protein interaction (PPI) networks and identified hub genes in viral activity and cytokine secretion. Our findings may help clinicians and researchers gain more insight into the pathogenesis of SARS-CoV-2 and design therapeutic strategies for COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Smoking / Gene Expression Regulation, Enzymologic / Coronavirus Infections / Peptidyl-Dipeptidase A / Betacoronavirus / Lung Type of study: Experimental Studies / Prognostic study Limits: Humans Language: English Journal: J Autoimmun Journal subject: Allergy and Immunology Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Smoking / Gene Expression Regulation, Enzymologic / Coronavirus Infections / Peptidyl-Dipeptidase A / Betacoronavirus / Lung Type of study: Experimental Studies / Prognostic study Limits: Humans Language: English Journal: J Autoimmun Journal subject: Allergy and Immunology Year: 2020 Document Type: Article