Harnessing innate immunity to eliminate SARS-CoV-2 and ameliorate COVID-19 disease.

Golonka, Rachel M; Saha, Piu; Yeoh, Beng San; Chattopadhyay, Saurabh; Gewirtz, Andrew T; Joe, Bina; Vijay-Kumar, Matam

Golonka, Rachel M; Saha, Piu; Yeoh, Beng San; Chattopadhyay, Saurabh; Gewirtz, Andrew T; Joe, Bina; Vijay-Kumar, Matam.

Golonka RM; UT Microbiome Consortium, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio.
Saha P; UT Microbiome Consortium, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio.
Yeoh BS; UT Microbiome Consortium, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio.
Chattopadhyay S; Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio.
Gewirtz AT; Center for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia.
Joe B; UT Microbiome Consortium, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio.
Vijay-Kumar M; UT Microbiome Consortium, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio.

Physiol Genomics ; 52(5): 217-221, 2020 05 01.

Article in English | MEDLINE | ID: covidwho-47305

Subject(s)

Betacoronavirus/pathogenicity; Coronavirus Infections/immunology; Coronavirus Infections/therapy; Flagellin/immunology; Flagellin/therapeutic use; Immunity, Innate/immunology; Neutrophils/immunology; Pneumonia, Viral/immunology; Pneumonia, Viral/therapy; Toll-Like Receptor 5/immunology; Animals; Antiviral Agents/pharmacology; Antiviral Agents/therapeutic use; Apoptosis Regulatory Proteins/metabolism; Betacoronavirus/immunology; COVID-19; Calcium-Binding Proteins/metabolism; Chemotherapy, Adjuvant; Coronavirus Infections/complications; Coronavirus Infections/prevention & control; Deoxyribonuclease I/metabolism; Deoxyribonuclease I/pharmacology; Deoxyribonuclease I/therapeutic use; Flagellin/administration & dosage; Humans; Immunity, Innate/drug effects; Inflammation/complications; Inflammation/immunology; Inflammation/pathology; Influenza A virus/immunology; Interferon-beta/biosynthesis; Interferon-beta/immunology; Interleukin-18/immunology; Mice; Models, Immunological; Neutrophils/drug effects; Neutrophils/metabolism; Pandemics/prevention & control; Peptides/therapeutic use; Pneumonia, Viral/complications; Pneumonia, Viral/prevention & control; Pseudomonas aeruginosa/immunology; Severe acute respiratory syndrome-related coronavirus/immunology; SARS-CoV-2; Toll-Like Receptor 5/agonists

Keywords

deoxyribonuclease I; flagellin; interferon; neutrophil extracellular traps; toll-like receptor 5

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Toll-Like Receptor 5 / Flagellin / Betacoronavirus / Immunity, Innate / Neutrophils Type of study: Prognostic study Topics: Long Covid Language: English Journal: Physiol Genomics Journal subject: Molecular Biology Year: 2020 Document Type: Article

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