Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study.
Eur Respir J
; 55(5)2020 05.
Article
in English
| MEDLINE | ID: covidwho-47800
ABSTRACT
The aim of this study was to identify factors associated with the death of patients with COVID-19 pneumonia caused by the novel coronavirus SARS-CoV-2.All clinical and laboratory parameters were collected prospectively from a cohort of patients with COVID-19 pneumonia who were hospitalised to Wuhan Pulmonary Hospital (Wuhan City, Hubei Province, China) between 25 December 2019 and 7 February 2020. Univariate and multivariate logistic regression analysis revealed that age ≥65 years (OR 3.765, 95% CI 1.14617.394; p=0.023), pre-existing concurrent cardiovascular or cerebrovascular diseases (OR 2.464, 95% CI 0.7558.044; p=0.007), CD3+CD8+ T-cells ≤75 cells·µL−1 (OR 3.982, 95% CI 1.13214.006; p<0.001) and cardiac troponin I ≥0.05â
ng·mL−1 (OR 4.077, 95% CI 1.16614.253; p<0.001) were associated with an increase in risk of mortality from COVID-19 pneumonia." has been corrected to "Univariate and multivariate logistic regression analysis revealed that age ≥65 years (OR 3.765, 95% CI 1.201−11.803; p=0.023), pre-existing concurrent cardiovascular or cerebrovascular diseases (OR 2.464, 95% CI 1.279−4.747; p=0.007), CD3+CD8+ T-cells ≤75 cells·µL−1 (OR 3.982, 95% CI 1.7619.004; p<0.001) and cardiac troponin I ≥0.05â
ng·mL−1 (OR 4.077, 95% CI 1.7789.349; p<0.001) were associated with an increase in risk of mortality from COVID-19 pneumonia. In a sex-, age- and comorbid illness-matched case-control study, CD3+CD8+ T-cells ≤75â
cells·µL-1 and cardiac troponin I ≥0.05â
ng·mL-1 remained as predictors for high mortality from COVID-19 pneumonia.We identified four risk factors age ≥65â
years, pre-existing concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+ T-cells ≤75â
cells·µL-1 and cardiac troponin I ≥0.05â
ng·mL-1 The latter two factors, especially, were predictors for mortality of COVID-19 pneumonia patients.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Coronavirus Infections
/
Coronavirus
Type of study:
Cohort study
/
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
English
Year:
2020
Document Type:
Article
Affiliation country:
13993003.00524-2020
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