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Maternal choline and respiratory coronavirus effects on fetal brain development.
Freedman, Robert; Hunter, Sharon K; Law, Amanda J; D'Alessandro, Angelo; Noonan, Kathleen; Wyrwa, Anna; Camille Hoffman, M.
  • Freedman R; Department of Psychiatry, University of Colorado School of Medicine, Aurora, CO, 80045, USA. Electronic address: Robert.Freedman@cuanschutz.edu.
  • Hunter SK; Department of Psychiatry, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
  • Law AJ; Department of Psychiatry, University of Colorado School of Medicine, Aurora, CO, 80045, USA; Department of Cell and Developmental Biology, USA.
  • D'Alessandro A; Department of Biochemistry and Molecular Genetics, USA.
  • Noonan K; Department of Psychiatry, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
  • Wyrwa A; Department of Psychiatry, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
  • Camille Hoffman M; Department of Psychiatry, University of Colorado School of Medicine, Aurora, CO, 80045, USA; Department of Obstetrics and Gynecology, Division of Maternal and Fetal Medicine, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
J Psychiatr Res ; 128: 1-4, 2020 09.
Article in English | MEDLINE | ID: covidwho-478074
ABSTRACT
Prenatal COVID-19 infection is anticipated by the U.S. Centers for Disease Control to affect fetal development similarly to other common respiratory coronaviruses through effects of the maternal inflammatory response on the fetus and placenta. Plasma choline levels were measured at 16 weeks gestation in 43 mothers who had contracted common respiratory viruses during the first 6-16 weeks of pregnancy and 53 mothers who had not. When their infants reached 3 months of age, mothers completed the Infant Behavior Questionnaire-Revised (IBQ-R), which assesses their infants' level of activity (Surgency), their fearfulness and sadness (Negativity), and their ability to maintain attention and bond to their parents and caretakers (Regulation). Infants of mothers who had contracted a moderately severe respiratory virus infection and had higher gestational choline serum levels (≥7.5 mM consistent with U.S. Food and Drug Administration dietary recommendations) had significantly increased development of their ability to maintain attention and to bond with their parents (Regulation), compared to infants whose mothers had contracted an infection but had lower choline levels (<7.5 mM). For infants of mothers with choline levels ≥7.5 µM, there was no effect of viral infection on infant IBQ-R Regulation, compared to infants of mothers who were not infected. Higher choline levels obtained through diet or supplements may protect fetal development and support infant early behavioral development even if the mother contracts a viral infection in early gestation when the brain is first being formed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Brain / Child Development / Choline / Infant Behavior / Fetal Development / Betacoronavirus Type of study: Experimental Studies / Observational study / Qualitative research Topics: Long Covid / Traditional medicine Language: English Journal: J Psychiatr Res Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Brain / Child Development / Choline / Infant Behavior / Fetal Development / Betacoronavirus Type of study: Experimental Studies / Observational study / Qualitative research Topics: Long Covid / Traditional medicine Language: English Journal: J Psychiatr Res Year: 2020 Document Type: Article