Type 1 interferons as a potential treatment against COVID-19.

Sallard, Erwan; Lescure, François-Xavier; Yazdanpanah, Yazdan; Mentre, France; Peiffer-Smadja, Nathan

Sallard, Erwan; Lescure, François-Xavier; Yazdanpanah, Yazdan; Mentre, France; Peiffer-Smadja, Nathan.

Sallard E; École Normale Supérieure de Paris, 45 Rue D'Ulm, 75005, Paris, France.
Lescure FX; Université de Paris, IAME, INSERM, F-75018, Paris, France; Department of Infectious and Tropical Diseases, Assistance Publique - Hôpitaux de Paris, Bichat-Claude Bernard University Hospital, 75018, Paris, France.
Yazdanpanah Y; Université de Paris, IAME, INSERM, F-75018, Paris, France; Department of Infectious and Tropical Diseases, Assistance Publique - Hôpitaux de Paris, Bichat-Claude Bernard University Hospital, 75018, Paris, France.
Mentre F; Université de Paris, IAME, INSERM, F-75018, Paris, France.
Peiffer-Smadja N; Université de Paris, IAME, INSERM, F-75018, Paris, France; Department of Infectious and Tropical Diseases, Assistance Publique - Hôpitaux de Paris, Bichat-Claude Bernard University Hospital, 75018, Paris, France. Electronic address: nathan.peiffer-smadja@inserm.fr.

Antiviral Res ; 178: 104791, 2020 06.

Article in English | MEDLINE | ID: covidwho-49066

ABSTRACT

ABSTRACT

Type 1 interferons have a broad antiviral activity in vitro and are currently evaluated in a clinical trial to treat MERS-CoV. In this review, we discuss preliminary data concerning the potential activity of type 1 interferons on SARS-CoV-2, and the relevance of evaluating these molecules in clinical trials for the treatment of COVID-19.

Subject(s)

Antiviral Agents/therapeutic use; Coronavirus Infections/drug therapy; Interferon Type I/therapeutic use; Pneumonia, Viral/drug therapy; Betacoronavirus/isolation & purification; COVID-19; Coronavirus Infections/virology; Humans; Pandemics; Pneumonia, Viral/virology; SARS-CoV-2

Keywords

COVID-19; Interferon; SARS-CoV-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / Interferon Type I / Coronavirus Infections Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Antiviral Res Year: 2020 Document Type: Article Affiliation country: J.antiviral.2020.104791

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