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SARS-CoV-2 serology: Test, test, test, but interpret with caution!
Bermingham, William H; Wilding, Thomas; Beck, Sarah; Huissoon, Aarnoud.
  • Bermingham WH; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK william.bermingham@nhs.net.
  • Wilding T; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
  • Beck S; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
  • Huissoon A; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Clin Med (Lond) ; 20(4): 365-368, 2020 07.
Article in English | MEDLINE | ID: covidwho-505874
ABSTRACT
SARS-CoV-2 serological tests are a subject of intense interest and have the potential to significantly enhance the diagnostic capability of healthcare services in the current pandemic. However, as with all novel assays, significant validation is required to understand the clinical relevance of results. We present the first study to assess clinician interpretation of SARS-CoV-2 serology scenarios. We identify common key assumptions regarding patient infectivity and protection that are not currently supported by the SARS-CoV-2 evidence base. In this rapidly developing field, we therefore strongly recommend serological assay results are accompanied by clear interpretive support from laboratory and infectious diseases specialists.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Clinical Laboratory Techniques / Clinical Decision-Making / Betacoronavirus / Antibodies, Viral Type of study: Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Clin Med (Lond) Year: 2020 Document Type: Article Affiliation country: Clinmed.2020-0170

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Clinical Laboratory Techniques / Clinical Decision-Making / Betacoronavirus / Antibodies, Viral Type of study: Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Clin Med (Lond) Year: 2020 Document Type: Article Affiliation country: Clinmed.2020-0170