SARS-CoV-2 SPIKE PROTEIN: an optimal immunological target for vaccines.

Salvatori, Giovanni; Luberto, Laura; Maffei, Mariano; Aurisicchio, Luigi; Roscilli, Giuseppe; Palombo, Fabio; Marra, Emanuele

Salvatori, Giovanni; Luberto, Laura; Maffei, Mariano; Aurisicchio, Luigi; Roscilli, Giuseppe; Palombo, Fabio; Marra, Emanuele.

Salvatori G; Takis s.r.l, Via di Castel Romano 100, 00128, Rome, Italy.
Luberto L; Takis s.r.l, Via di Castel Romano 100, 00128, Rome, Italy.
Maffei M; Evvivax s.r.l, Via di Castel Romano, 100, 00128, Rome, Italy.
Aurisicchio L; Takis s.r.l, Via di Castel Romano 100, 00128, Rome, Italy.
Roscilli G; Evvivax s.r.l, Via di Castel Romano, 100, 00128, Rome, Italy.
Palombo F; Takis s.r.l, Via di Castel Romano 100, 00128, Rome, Italy.
Marra E; Evvivax s.r.l, Via di Castel Romano, 100, 00128, Rome, Italy.

J Transl Med ; 18(1): 222, 2020 06 03.

Article in English | MEDLINE | ID: covidwho-505907

ABSTRACT

ABSTRACT

COVID-19 has rapidly spread all over the world, progressing into a pandemic. This situation has urgently impelled many companies and public research institutes to concentrate their efforts on research for effective therapeutics. Here, we outline the strategies and targets currently adopted in developing a vaccine against SARS-CoV-2. Based on previous evidence and experience with SARS and MERS, the primary focus has been the Spike protein, considered as the ideal target for COVID-19 immunotherapies.

Subject(s)

Betacoronavirus/immunology; Coronavirus Infections/prevention & control; Pandemics/prevention & control; Pneumonia, Viral/prevention & control; Spike Glycoprotein, Coronavirus/immunology; Viral Vaccines/immunology; Animals; Antibodies, Viral/adverse effects; Antibodies, Viral/biosynthesis; Antibody-Dependent Enhancement/immunology; Betacoronavirus/genetics; Betacoronavirus/pathogenicity; COVID-19; COVID-19 Vaccines; Coronavirus Infections/epidemiology; Coronavirus Infections/genetics; Coronavirus Infections/immunology; Humans; Pneumonia, Viral/epidemiology; Pneumonia, Viral/immunology; SARS-CoV-2; Spike Glycoprotein, Coronavirus/chemistry; Spike Glycoprotein, Coronavirus/genetics; Translational Research, Biomedical; Viral Vaccines/adverse effects; Viral Vaccines/genetics

Keywords

SARS-CoV-2; SPIKE protein; Vaccine

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Viral Vaccines / Coronavirus Infections / Pandemics / Spike Glycoprotein, Coronavirus / Betacoronavirus Type of study: Observational study Topics: Vaccines Limits: Animals / Humans Language: English Journal: J Transl Med Year: 2020 Document Type: Article Affiliation country: S12967-020-02392-y

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