Thromboinflammatory response in SARS-CoV-2 sepsis.

Maiese, Aniello; Passaro, Giovanna; Matteis, Alessandra DE; Fazio, Valentina; Raffaele, La Russa; Paolo, Marco Di

Maiese, Aniello; Passaro, Giovanna; Matteis, Alessandra DE; Fazio, Valentina; Raffaele, La Russa; Paolo, Marco Di.

Maiese A; Department of Surgical Pathology, Medical, Molecular and Critical Area, Institute of Legal Medicine, University of Pisa, Pisa, Italy.
Passaro G; Gemelli IRCCS Research Hospital, Fondazione Policlinico Universitario A. Rome, Italy.
Matteis A; Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Rome, Italy.
Fazio V; Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Rome, Italy.
Raffaele R; Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Rome, Italy.
Paolo MD; Department of Surgical Pathology, Medical, Molecular and Critical Area, Institute of Legal Medicine, University of Pisa, Pisa, Italy.

Med Leg J ; 88(2): 78-80, 2020 Jul.

Article in English | MEDLINE | ID: covidwho-506028

ABSTRACT

ABSTRACT

Viral sepsis is rare, and its real incidence is not known. SARS-CoV-2 infection causes the release of a significant amount of pro-inflammatory cytokines that aggravates interstitial pneumonia and evolves in viral sepsis with prominent hypercoagulability. We believe it is useful and advisable to establish early immunomodulator therapy and the prophylaxis anticoagulant therapy should be rethought.

Subject(s)

Betacoronavirus; Coronavirus Infections/complications; Cytokines/blood; Pneumonia, Viral/complications; Sepsis/virology; Thrombosis/virology; Age Factors; Anticoagulants/therapeutic use; Biomarkers/blood; COVID-19; Comorbidity; Coronavirus Infections/drug therapy; Fibrin Fibrinogen Degradation Products/analysis; Humans; Immunosuppressive Agents/therapeutic use; Pandemics; Pneumonia, Viral/drug therapy; SARS-CoV-2; Sepsis/blood; Thrombosis/prevention & control

Keywords

Sars-CoV-2; sepsis, COVID-19, Thrombosis, Coagulopathy

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Thrombosis / Cytokines / Coronavirus Infections / Sepsis / Betacoronavirus Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Med Leg J Year: 2020 Document Type: Article Affiliation country: 0025817220926915

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