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COVID-19 in teriflunomide-treated patients with multiple sclerosis.
Maghzi, Amir Hadi; Houtchens, Maria K; Preziosa, Paolo; Ionete, Carolina; Beretich, Biljana D; Stankiewicz, James M; Tauhid, Shahamat; Cabot, Ann; Berriosmorales, Idanis; Schwartz, Tamara H W; Sloane, Jacob A; Freedman, Mark S; Filippi, Massimo; Weiner, Howard L; Bakshi, Rohit.
  • Maghzi AH; Department of Neurology, Ann Romney Center for Neurologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Mailbox 9002L, Boston, MA, 02115, USA.
  • Houtchens MK; Department of Neurology, Ann Romney Center for Neurologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Mailbox 9002L, Boston, MA, 02115, USA.
  • Preziosa P; Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Ionete C; Department of Neurology, University of Massachusetts, Worcester, MA, USA.
  • Beretich BD; Department of Neurology, Maine Medical Center, Portland, ME, USA.
  • Stankiewicz JM; Department of Neurology, Ann Romney Center for Neurologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Mailbox 9002L, Boston, MA, 02115, USA.
  • Tauhid S; Department of Neurology, Ann Romney Center for Neurologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Mailbox 9002L, Boston, MA, 02115, USA.
  • Cabot A; Department of Neurology, Concord Hospital, Concord, NH, USA.
  • Berriosmorales I; Department of Neurology, University of Massachusetts, Worcester, MA, USA.
  • Schwartz THW; Department of Neurology, Maine Medical Center, Portland, ME, USA.
  • Sloane JA; Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Freedman MS; University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, ON, Canada.
  • Filippi M; Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Weiner HL; Vita-Salute San Raffaele University, Milan, Italy.
  • Bakshi R; Department of Neurology, Ann Romney Center for Neurologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Mailbox 9002L, Boston, MA, 02115, USA.
J Neurol ; 267(10): 2790-2796, 2020 Oct.
Article in English | MEDLINE | ID: covidwho-506032
ABSTRACT
The outbreak of a severe acute respiratory syndrome caused by a novel coronavirus (COVID-19), has raised health concerns for patients with multiple sclerosis (MS) who are commonly on long-term immunotherapies. Managing MS during the pandemic remains challenging with little published experience and no evidence-based guidelines. We present five teriflunomide-treated patients with MS who subsequently developed active COVID-19 infection. The patients continued teriflunomide therapy and had self-limiting infection, without relapse of their MS. These observations have implications for the management of MS in the setting of the COVID-19 pandemic.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Toluidines / Crotonates / Coronavirus Infections / Immunosuppressive Agents / Multiple Sclerosis Type of study: Case report / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: J Neurol Year: 2020 Document Type: Article Affiliation country: S00415-020-09944-8

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Toluidines / Crotonates / Coronavirus Infections / Immunosuppressive Agents / Multiple Sclerosis Type of study: Case report / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: J Neurol Year: 2020 Document Type: Article Affiliation country: S00415-020-09944-8