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The clinical and immunological features of pediatric COVID-19 patients in China.
Chen, Juan; Zhang, Zhen-Zhen; Chen, Yao-Kai; Long, Quan-Xin; Tian, Wen-Guang; Deng, Hai-Jun; Hu, Jie-Li; Zhang, Xian-Xiang; Xiang, Jiang-Lin; Wang, Dao-Xin; Hu, Peng; Zhou, Fa-Chun; Li, Zhi-Jie; Xu, Hong-Mei; Cai, Xue-Fei; Wang, De-Qiang; Hu, Yuan; Tang, Ni; Liu, Bei-Zhong; Wu, Gui-Cheng; Huang, Ai-Long.
  • Chen J; The Key Laboratory of Molecular Biology of Infectious Diseases Designated By the Chinese Ministry of Education, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
  • Zhang ZZ; Department of Infectious Diseases, National Clinical Research Center for Child Health and Disorders, The Children's Hospital of Chongqing Medical University, Chongqing, China.
  • Chen YK; Division of Infectious Diseases, Chonqging Public Health Medical Center, Chongqing, China.
  • Long QX; The Key Laboratory of Molecular Biology of Infectious Diseases Designated By the Chinese Ministry of Education, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
  • Tian WG; Department of Infectious Diseases, Yongchuan Hospital Affiliated to Chongqing Medical University, Chongqing, China.
  • Deng HJ; The Key Laboratory of Molecular Biology of Infectious Diseases Designated By the Chinese Ministry of Education, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
  • Hu JL; The Key Laboratory of Molecular Biology of Infectious Diseases Designated By the Chinese Ministry of Education, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
  • Zhang XX; Department of Endocrinology, Chongqing Three Gorges Central Hospital, Chongqing, China.
  • Pu-Liao; Department of Clinical Laboratory, Chongqing People's Hospital, Chongqing, China.
  • Xiang JL; Department of Infectious Diseases, Chongqing Three Gorges Central Hospital, Chongqing, China.
  • Wang DX; Department of Respiration, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China.
  • Hu P; The Key Laboratory of Molecular Biology of Infectious Diseases Designated By the Chinese Ministry of Education, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
  • Zhou FC; Department of Emergency, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China.
  • Li ZJ; Department of Endocrinology, Chongqing Three Gorges Central Hospital, Chongqing, China.
  • Xu HM; Department of Infectious Diseases, National Clinical Research Center for Child Health and Disorders, The Children's Hospital of Chongqing Medical University, Chongqing, China.
  • Cai XF; The Key Laboratory of Molecular Biology of Infectious Diseases Designated By the Chinese Ministry of Education, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
  • Wang DQ; The Key Laboratory of Molecular Biology of Infectious Diseases Designated By the Chinese Ministry of Education, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
  • Hu Y; The Key Laboratory of Molecular Biology of Infectious Diseases Designated By the Chinese Ministry of Education, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
  • Tang N; The Key Laboratory of Molecular Biology of Infectious Diseases Designated By the Chinese Ministry of Education, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
  • Liu BZ; Department of Clinical Laboratory, Yongchuan Hospital Affiliated to Chongqing Medical University, Chongqing, China.
  • Wu GC; Department of Liver Disease, Chongqing Three Gorges Central Hospital, Chongqing, China.
  • Huang AL; The Key Laboratory of Molecular Biology of Infectious Diseases Designated By the Chinese Ministry of Education, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Genes Dis ; 7(4): 535-541, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-52595
Semantic information from SemMedBD (by NLM)
1. Coronavirus Infections CAUSES COVID-19
Subject
Coronavirus Infections
Predicate
CAUSES
Object
COVID-19
2. Diarrhea PROCESS_OF Patients
Subject
Diarrhea
Predicate
PROCESS_OF
Object
Patients
3. Diarrhea COEXISTS_WITH Disease
Subject
Diarrhea
Predicate
COEXISTS_WITH
Object
Disease
4. Symptoms COEXISTS_WITH Three or Four Days
Subject
Symptoms
Predicate
COEXISTS_WITH
Object
Three or Four Days
5. exposure history PROCESS_OF Child
Subject
exposure history
Predicate
PROCESS_OF
Object
Child
6. Coronavirus Infections CAUSES COVID-19
Subject
Coronavirus Infections
Predicate
CAUSES
Object
COVID-19
7. Diarrhea PROCESS_OF Patients
Subject
Diarrhea
Predicate
PROCESS_OF
Object
Patients
8. Diarrhea COEXISTS_WITH Disease
Subject
Diarrhea
Predicate
COEXISTS_WITH
Object
Disease
9. Symptoms COEXISTS_WITH Three or Four Days
Subject
Symptoms
Predicate
COEXISTS_WITH
Object
Three or Four Days
10. exposure history PROCESS_OF Child
Subject
exposure history
Predicate
PROCESS_OF
Object
Child
ABSTRACT
In December 2019, the corona virus disease 2019 (COVID-19) caused by novel coronavirus (SARS-CoV-2) emerged in Wuhan, China and rapidly spread worldwide. Few information on clinical features and immunological profile of COVID-19 in paediatrics. The clinical features and treatment outcomes of twelve paediatric patients confirmed as COVID-19 were analyzed. The immunological features of children patients was investigated and compared with twenty adult patients. The median age was 14.5-years (range from 0.64 to 17), and six of the patients were male. The average incubation period was 8 days. Clinically, cough (9/12, 75%) and fever (7/12, 58.3%) were the most common symptoms. Four patients (33.3%) had diarrhea during the disease. As to the immune profile, children had higher amount of total T cell, CD8+ T cell and B cell but lower CRP levels than adults (P < 0.05). Ground-glass opacity (GGO) and local patchy shadowing were the typical radiological findings on chest CT scan. All patients received antiviral and symptomatic treatment and the symptom relieved in 3-4 days after admitted to hospital. The paediatric patients showed mild symptom but with longer incubation period. Children infected with SARS-CoV-2 had different immune profile with higher T cell amount and low inflammatory factors level, which might ascribed to the mild clinical symptom. We advise that nucleic acid test or examination of serum IgM/IgG antibodies against SARS-CoV-2 should be taken for children with exposure history regardless of clinical symptom.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Topics: Long Covid Language: English Journal: Genes Dis Year: 2020 Document Type: Article Affiliation country: J.gendis.2020.03.008

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Full text: Available Collection: International databases Database: MEDLINE Topics: Long Covid Language: English Journal: Genes Dis Year: 2020 Document Type: Article Affiliation country: J.gendis.2020.03.008