Terminal complement inhibition dampens the inflammation during COVID-19.

Kulasekararaj, Austin G; Lazana, Ioanna; Large, Joanna; Posadas, Kristina; Eagleton, Helen; Lord Villajin, John; Zuckerman, Mark; Gandhi, Shreyans; Marsh, Judith C W

Kulasekararaj, Austin G; Lazana, Ioanna; Large, Joanna; Posadas, Kristina; Eagleton, Helen; Lord Villajin, John; Zuckerman, Mark; Gandhi, Shreyans; Marsh, Judith C W.

Kulasekararaj AG; Department of Haematological Medicine, King's College Hospital-NHS Foundation Trust, London, UK.
Lazana I; NIHR/Wellcome King's Clinical Research Facility, London, UK.
Large J; King's College London, London, UK.
Posadas K; Department of Haematological Medicine, King's College Hospital-NHS Foundation Trust, London, UK.
Eagleton H; Department of Haematological Medicine, King's College Hospital-NHS Foundation Trust, London, UK.
Lord Villajin J; NIHR/Wellcome King's Clinical Research Facility, London, UK.
Zuckerman M; Department of Haematology, Stoke Mandeville Hospital, Buckinghamshire, UK.
Gandhi S; NIHR/Wellcome King's Clinical Research Facility, London, UK.
Marsh JCW; South London Specialist Virology Centre, King's College Hospital NHS Foundation Trust, London, UK.

Br J Haematol ; 190(3): e141-e143, 2020 08.

Article in English | MEDLINE | ID: covidwho-526519

Subject(s)

Betacoronavirus; Complement Inactivating Agents/therapeutic use; Coronavirus Infections/drug therapy; Hemoglobinuria, Paroxysmal/drug therapy; Inflammation/drug therapy; Pneumonia, Viral/drug therapy; Adult; COVID-19; Complement Activation/drug effects; Complement Inactivating Agents/pharmacology; Coronavirus Infections/complications; Coronavirus Infections/immunology; Female; Hemoglobinuria, Paroxysmal/complications; Hemoglobinuria, Paroxysmal/immunology; Hemolysis/drug effects; Humans; Male; Middle Aged; Pandemics; Pneumonia, Viral/complications; Pneumonia, Viral/immunology; SARS-CoV-2

Keywords

C5 inhibition; COVID-19; complement activation; paroxysmal nocturnal haemoglobinuria

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Complement Inactivating Agents / Betacoronavirus / Hemoglobinuria, Paroxysmal / Inflammation Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Br J Haematol Year: 2020 Document Type: Article Affiliation country: Bjh.16916

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