Your browser doesn't support javascript.
Obesity prolongs the hospital stay in patients affected by COVID-19, and may impact on SARS-COV-2 shedding.
Moriconi, Diego; Masi, Stefano; Rebelos, Eleni; Virdis, Agostino; Manca, Maria Laura; De Marco, Salvatore; Taddei, Stefano; Nannipieri, Monica.
  • Moriconi D; Department of Clinical and Experimental Medicine, University of Pisa, Italy. Electronic address: d.moriconi@ao-pisa.toscana.it.
  • Masi S; Department of Clinical and Experimental Medicine, University of Pisa, Italy. Electronic address: stefano.masi@unipi.it.
  • Rebelos E; Department of Clinical and Experimental Medicine, University of Pisa, Italy. Electronic address: elenirebelos@gmail.com.
  • Virdis A; Department of Clinical and Experimental Medicine, University of Pisa, Italy. Electronic address: agostino.virdis@unipi.it.
  • Manca ML; Department of Clinical and Experimental Medicine, University of Pisa, Italy. Electronic address: l.manca@med.unipi.it.
  • De Marco S; Azienda Ospedaliero Universitaria Pisa, AOUP, Pisa, Italy. Electronic address: s.demarco@ao-pisa.toscana.it.
  • Taddei S; Department of Clinical and Experimental Medicine, University of Pisa, Italy. Electronic address: stefano.taddei@unipi.it.
  • Nannipieri M; Department of Clinical and Experimental Medicine, University of Pisa, Italy. Electronic address: monica.nannipieri@dmi.unipi.it.
Obes Res Clin Pract ; 14(3): 205-209, 2020.
Article in English | MEDLINE | ID: covidwho-526634
Semantic information from SemMedBD (by NLM)
1. Obesity PROCESS_OF Patients
Subject
Obesity
Predicate
PROCESS_OF
Object
Patients
2. COVID-19 AFFECTS Patients
Subject
COVID-19
Predicate
AFFECTS
Object
Patients
3. Pneumonia PROCESS_OF Patients
Subject
Pneumonia
Predicate
PROCESS_OF
Object
Patients
4. Obesity COEXISTS_WITH Hypertensive disease
Subject
Obesity
Predicate
COEXISTS_WITH
Object
Hypertensive disease
5. COVID-19 AFFECTS Obesity
Subject
COVID-19
Predicate
AFFECTS
Object
Obesity
6. Obesity PROCESS_OF Patients
Subject
Obesity
Predicate
PROCESS_OF
Object
Patients
7. COVID-19 AFFECTS Patients
Subject
COVID-19
Predicate
AFFECTS
Object
Patients
8. Pneumonia PROCESS_OF Patients
Subject
Pneumonia
Predicate
PROCESS_OF
Object
Patients
9. Obesity COEXISTS_WITH Hypertensive disease
Subject
Obesity
Predicate
COEXISTS_WITH
Object
Hypertensive disease
10. COVID-19 AFFECTS Obesity
Subject
COVID-19
Predicate
AFFECTS
Object
Obesity
ABSTRACT

INTRODUCTION:

On the last three months the new SARS-COV-2 coronavirus has created a pandemic, rapidly spreading all around the world. The aim of the study is to investigate whether obesity impacts on COVID-19 morbidity.

METHODS:

One hundred consecutive patients with COVID-19 pneumonia admitted in our Medical Unit were evaluated. Anthropometric parameters and past medical history were registered. Nasopharyngeal swab samples and biochemical analysis were obtained at admission and during hospital stay.

RESULTS:

Patients with (OB, 29) and without obesity (N-OB, 71) were similar in age, gender and comorbidities, with the exception of hypertension that was more frequent in OB group. At admission, inflammatory markers were higher in OB than N-OB group. OB group showed a worse pulmonary clinical picture, with lower PaO2 (57 ± 15 vs. 68 ± 14 mmHg, p = 0.042), and SaO2 (88 ± 6 vs. 92 ± 5%, p = 0.049) at admission consequently requiring higher volumes of oxygen (Fi02 38 ± 15 vs. 29 ± 19%, p = 0.047) and a longer period to achieve oxygen weaning (10 ± 6 vs. 15 ± 7 days, p = 0.03). OB group also had positive swabs for longer time (19 ± 8 vs. 13 ± 7, days, p = 0.002), and required longer hospital stay (21 ± 8 vs. 13 ± 8, days, p = 0.0008). Partial least square regression analysis showed that BMI, age and CRP at admission were related to longer length of hospital stay, and time for negative swab. On the contrary, in this cohort, obesity did not predict higher mortality.

CONCLUSIONS:

Subjects with obesity affected by COVID-19 require longer hospitalization, more intensive and longer oxygen treatment, and they may have longer SARS-COV-2 shedding.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Virus Shedding / Coronavirus Infections / Betacoronavirus / Length of Stay / Obesity Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male Country/Region as subject: Europa Language: English Journal: Obes Res Clin Pract Year: 2020 Document Type: Article

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Virus Shedding / Coronavirus Infections / Betacoronavirus / Length of Stay / Obesity Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male Country/Region as subject: Europa Language: English Journal: Obes Res Clin Pract Year: 2020 Document Type: Article