Immediate and long-term consequences of COVID-19 infections for the development of neurological disease.
Alzheimers Res Ther
; 12(1): 69, 2020 06 04.
Article
in English
| MEDLINE | ID: covidwho-526712
ABSTRACT
Increasing evidence suggests that infection with Sars-CoV-2 causes neurological deficits in a substantial proportion of affected patients. While these symptoms arise acutely during the course of infection, less is known about the possible long-term consequences for the brain. Severely affected COVID-19 cases experience high levels of proinflammatory cytokines and acute respiratory dysfunction and often require assisted ventilation. All these factors have been suggested to cause cognitive decline. Pathogenetically, this may result from direct negative effects of the immune reaction, acceleration or aggravation of pre-existing cognitive deficits, or de novo induction of a neurodegenerative disease. This article summarizes the current understanding of neurological symptoms of COVID-19 and hypothesizes that affected patients may be at higher risk of developing cognitive decline after overcoming the primary COVID-19 infection. A structured prospective evaluation should analyze the likelihood, time course, and severity of cognitive impairment following the COVID-19 pandemic.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Brain
/
Coronavirus Infections
/
Neurodegenerative Diseases
/
Betacoronavirus
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
Topics:
Long Covid
Limits:
Animals
/
Humans
Language:
English
Journal:
Alzheimers Res Ther
Year:
2020
Document Type:
Article
Affiliation country:
S13195-020-00640-3
Similar
MEDLINE
...
LILACS
LIS