Inflammasomes and Pyroptosis as Therapeutic Targets for COVID-19.
J Immunol
; 205(2): 307-312, 2020 07 15.
Article
in English
| MEDLINE | ID: covidwho-542361
ABSTRACT
The inflammatory response to severe acute respiratory syndrome-related coronavirus 2 infection has a direct impact on the clinical outcomes of coronavirus disease 2019 patients. Of the many innate immune pathways that are engaged by severe acute respiratory syndrome-related coronavirus 2, we highlight the importance of the inflammasome pathway. We discuss available pharmaceutical agents that target a critical component of inflammasome activation, signaling leading to cellular pyroptosis, and the downstream cytokines as a promising target for the treatment of severe coronavirus disease 2019-associated diseases.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Inflammasomes
/
Pyroptosis
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
J Immunol
Year:
2020
Document Type:
Article
Affiliation country:
Jimmunol.2000513
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