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Pattern of liver injury in adult patients with COVID-19: a retrospective analysis of 105 patients.
Wang, Qi; Zhao, Hong; Liu, Li-Gai; Wang, Yan-Bin; Zhang, Ting; Li, Ming-Hui; Xu, Yan-Li; Gao, Gui-Ju; Xiong, Hao-Feng; Fan, Ying; Cao, Ying; Ding, Rui; Wang, Jing-Jing; Cheng, Cheng; Xie, Wen.
  • Wang Q; Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100,015, China.
  • Zhao H; Beijing Key Laboratory of Emerging Infectious Diseases, Beijing, 100,015, China.
  • Liu LG; Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100,015, China.
  • Wang YB; Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100,015, China.
  • Zhang T; Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100,015, China.
  • Li MH; Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100,015, China.
  • Xu YL; Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100,015, China.
  • Gao GJ; Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100,015, China.
  • Xiong HF; Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100,015, China.
  • Fan Y; Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, 100,015, China.
  • Cao Y; Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100,015, China.
  • Ding R; Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100,015, China.
  • Wang JJ; Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100,015, China.
  • Cheng C; Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100,015, China.
  • Xie W; Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100,015, China.
Mil Med Res ; 7(1): 28, 2020 06 07.
Article in English | MEDLINE | ID: covidwho-548559
ABSTRACT

BACKGROUND:

Recent studies reported that patients with coronavirus disease-2019 (COVID-19) might have liver injury. However, few data on the combined analysis and change patterns of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBil) have been shown.

METHODS:

This is a single-center retrospective study. A total of 105 adult patients hospitalized for confirmed COVID-19 in Beijing Ditan Hospital between January 12, and March 17, 2020 were included, and divided into mild group (n = 79) and severe group(n = 26). We compared liver functional test results between the two groups. Category of ALT change during the disease course was also examined.

RESULTS:

56.2% (59/105) of the patients had unnormal ALT, AST, or total TBil throughout the course of the disease, but in 91.4% (96/105) cases the level of ALT, AST or TBil ≤3 fold of the upper limit of normal reference range (ULN). The overall distribution of ALT, AST, and TBil were all significantly difference between mild and severe group (P <  0.05). The percentage of the patients with elevated both ALT and AST was 12.7% (10/79) in mild cases vs. 46.2% (12/26) in severe cases (P = 0.001). 34.6% (9/26) severe group patients started to have abnormal ALT after admission, and 73.3% (77/105) of all patients had normal ALT before discharge.

CONCLUSIONS:

Elevated liver function index is very common in patients with COVID-19 infection, and the level were less than 3 × ULN, but most are reversible. The abnormality of 2 or more indexes is low in the patients with COVID-19, but it is more likely to occur in the severe group.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Alanine Transaminase / Betacoronavirus / Hepatitis, Viral, Human / Liver Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Mil Med Res Year: 2020 Document Type: Article Affiliation country: S40779-020-00256-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Alanine Transaminase / Betacoronavirus / Hepatitis, Viral, Human / Liver Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Mil Med Res Year: 2020 Document Type: Article Affiliation country: S40779-020-00256-6